Does the science of peptides live up to the hype?

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Short Wave 15 min 10 speakers 3 chapters transcribed 1 month ago
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What real-world harms prompted this investigation into peptides?

Will James 0:00
The last time Antonio Mays Sr. heard from his son, it was in a note the 16-year-old left in the family's garage. He told me he was going to make me proud. Antonio Jr. left home to join a protest in Seattle. A week later, he was shot and killed there. I need some arrest made, justice for my son. Listen to We Keep Us Safe on the Embedded podcast from NPR.
Regina Barber 0:24
Hey Short Wavers, Regina Barber here. Maybe you've listened to us because we were in your daily drive and you were a casual acquaintance. Sadly, the daily drive is gone. So to keep this friendship going, we need you to be proactive and click to follow Shortwave in your podcast app. That way you'll never miss the show, which is starting right now. You're listening to Shortwave from NPR. Today we're talking about peptides. They're all the rage among fitness influencers and people seeking new options for other conditions like chronic pain. But lots of scientists have big concerns about their safety. So we're getting into it with health reporter Sarah Bowden, who's covered this topic for NPR. Hey, Sarah.
Regina Barber 1:07
Hey, thanks for having me. Yeah, I'm excited that you're here because I keep hearing about peptides. What is the deal?
Sarah Boden 1:14
So a peptide is a string of amino acids that's smaller than a protein. And your body probably has millions of different peptides. And these peptides do different things like regulate immune function or grow certain cells, control hormones. For example, most people have heard of insulin. That's a peptide. The hormone oxytocin is also a peptide. And some of these peptides are getting even more time in the limelight this week because seven commonly used peptides are up for consideration by the FDA's compounding pharmacy board. They're holding a two-day meeting later this week.
Regina Barber 1:54
Okay, so peptides, they're definitely not a new thing.
Sarah Boden 1:57
No, no, definitely not. But what is new is that a lot of fitness influencers and tech bros and celebrities are really excited about synthetic peptides, which sources I spoke with would consider a type of medication. And anecdotally, people report various peptides have helped them with muscle recovery and immune function. Some people say different combinations of peptides can slow aging.
Regina Barber 2:24
Today on the show, the peptide promise. Are peptides all they're cracked up to be? And is what you get from an influencer online the same as getting it from your doctor? You're listening to Shortwave, a science podcast from NPR.
Tanya Mosley 2:48
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Regina Barber 3:58
Okay, Sarah, let's get into it. What does data say about peptides? Is there proof to this idea that peptides can help people with muscle recovery and immune function, even slow down aging?
Sarah Boden 4:11
I'm asking for a friend, totally. I mean, it depends on which peptide we're talking about because there are so many different peptides. For example, GLP-1 weight loss drugs, the active ingredient in those is a peptide. And these medications have been studied for safety and efficacy. But with a lot of the more popular peptides, like maybe you've heard of BPC-157.

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