Talking Points

Evolution of Pharmacotherapy in STEMI

01 Apr 2026

Contributed by Lukas

How has the pharmacotherapy for STEMI changed over the past 46 years? Ginger Jiang and C. Michael Gibson discuss treating patients with zalunfiban at ...

The CorCMR Trial

04 Mar 2026

Contributed by Lukas

Colin Berry and C. Michael Gibson discuss whether stress CMR imaging is helpful in patients with angina and no obstructive CAD.

The TUXEDO-2 Trial

04 Feb 2026

Contributed by Lukas

Sripal Bangalore and C. Michael Gibson discuss whether ticagrelor is noninferior to prasugrel in patients with diabetes and multivessel CAD undergoing...

The FLOW Trial

07 Jan 2026

Contributed by Lukas

C. Michael Gibson talks to Katherine Tuttle about semaglutide's positive effects in patients with diabetes and chronic kidney disease.

The 2024 ESC CCS Guidelines

17 Dec 2025

Contributed by Lukas

Mamas Mamas, Nieves Gonzalo, and Erick Schampaert take a look at the latest guidelines for chronic coronary syndromes and how they relate to complex P...

The My Heart Your Heart Trial

10 Dec 2025

Contributed by Lukas

Thomas Crawford meets with C. Michael Gibson to discuss the role of reconditioned pacemakers in low- and middle-income countries.

The FAVOR III Europe Trial

03 Dec 2025

Contributed by Lukas

Mamas Mamas, Birgitte Krogsgaard Andersen, and Niels Ramsing Holm discuss QFR versus FFR for guiding resvascularization in patients with coronary sten...

The FLOW Trial

03 Dec 2025

Contributed by Lukas

C. Michael Gibson talks to Katherine Tuttle about semaglutide's positive effects in patients with diabetes and chronic kidney disease.

STORM-PE TRIAL

19 Nov 2025

Contributed by Lukas

James Benenati, Robert Lookstein, and Rachel Rosovsky discuss the STORM-PE trial, the first-of-its-kind RCT for acute intermediate-high risk pulmonary...

The EARLY TAVR and TAVR UNLOAD Trials

12 Nov 2025

Contributed by Lukas

For patients with aortic stenosis, is earlier intervention beneficial? Mamas Mamas, Philippe Généreux, Nicolas Van Mieghem, and Bernard Prendergast ...

The EPIC-CAD Trial

29 Oct 2025

Contributed by Lukas

Mamas Mamas and Gi-byoung Nam discuss edoxaban monotherapy in patients with high-risk AF and stable CAD.

The ECLIPSE Trial

01 Oct 2025

Contributed by Lukas

Ajay Kirtane and C. Michael Gibson discuss how orbital atherectomy compares with balloon angioplasty for severely calcified coronary arteries before D...

The CLEAR SYNERGY (OASIS 9) Trial

17 Sep 2025

Contributed by Lukas

Does long-term colchicine benefit patients after acute MI? C. Michael Gibson and Sanjit Jolly discuss. 097245

The NOTION-3 Trial

03 Sep 2025

Contributed by Lukas

Mamas Mamas talks to Jacob Thomsen Lønborg about how PCI affects outcomes for patients with stable CAD undergoing TAVI.

TMVR in the Heart Failure Paradigm

15 Aug 2025

Contributed by Lukas

Transcatheter devices are new to the heart failure (HF) community and treatment armamentarium for severe MR. This discussion focuses on the impact of ...

The ABYSS Trial

13 Aug 2025

Contributed by Lukas

Johanne Silvain, Gilles Montalescot, and C. Michael Gibson discuss the effects of beta-blocker interruption in post-MI patients.

Patient Selection and Treatment Goals

11 Aug 2025

Contributed by Lukas

Patient selection is important for transcatheter interventions and impacts result success. This discussion focuses on defining what treatment goals sh...

Women's Health Study: Biomarkers

06 Aug 2025

Contributed by Lukas

Paul Ridker and C. Michael Gibson discuss 30-year data hinting at how three modifiable factors—LDL, hs-CRP, and Lp(a)—might be leveraged to reduce...

Echocardiography and Quality Data

04 Aug 2025

Contributed by Lukas

Clinical trials face challenges with variability in echo images, protocol adherence, and data quality. This discussion focuses on strategies to improv...

Insights on Intrepid 2-Yr Mitral TF EFS

30 Jul 2025

Contributed by Lukas

The Intrepid TMVR system just released 2-year transfemoral EFS outcomes at NY Valves. This discussion provides a deeper dive into what this data means...

New ESC Guidelines for AF

23 Jul 2025

Contributed by Lukas

Renate Schnabel, Ruben Casado Arroyo, and Mamas Mamas discuss the atrial fibrillation recommendations unveiled at ESC Congress 2024.

The STEEER-AF Trial

09 Jul 2025

Contributed by Lukas

Dipak Kotecha talks to C. Michael Gibson about whether educating healthcare providers on rhythm-control therapy affects guideline adherence and stroke...

The EPIC-CAD Trial

02 Jul 2025

Contributed by Lukas

Gi-Byoung Nam, Duk-Woo Park, and C. Michael Gibson weigh edoxaban monotherapy vs dual antithrombotic therapy for patients with AF and stable coronary ...

Acute Coronary Care in Ethiopia

18 Jun 2025

Contributed by Lukas

Mamas Mamas talks to Tesfaye Telila about the landscape of acute coronary care in Ethiopa, where just a few dozen cardiologists contend with a populat...

The POPular PAUSE TAVI Trial

04 Jun 2025

Contributed by Lukas

Should we stop anticoagulation therapy before TAVI in patients with aortic stenosis? Dirk-Jan van Ginkel and C. Michael Gibson discuss.

The SENIOR-RITA Trial

21 May 2025

Contributed by Lukas

Vijay Kunadian talks to C. Michael Gibson about using an invasive or conservative strategy for older patients with NSTEMI.

The REDUCE-AMI Trial

07 May 2025

Contributed by Lukas

Troels Yndigegn, Sripal Bangalore, and Mamas Mamas discuss whether beta-blockers still benefit patients with acute MI and preserved ejection fraction.

The EARTH-STEMI Trial

16 Apr 2025

Contributed by Lukas

Gianluca Campo and C. Michael Gibson compare complete versus culprit-only revascularization in older STEMI patients.

The SCOFF Trial

09 Apr 2025

Contributed by Lukas

David Ferreira talks to C. Michael Gibson about the latest data showing patients don't need to fast ahead of cardiac catheterization.

The RESHAPE-HF2 and MATTERHORN Trials

02 Apr 2025

Contributed by Lukas

Mamas Mamas, Stefan Anker, and Volker Rudolph talk about their studies of MitraClip for functional MR in patients with heart failure.

The EMPACT-MI Trial

19 Mar 2025

Contributed by Lukas

Javed Butler and C. Michael Gibson discuss the trial testing early empagliflozin after acute MI.

The PROACT Trial

05 Mar 2025

Contributed by Lukas

Talking with C. Michael Gibson, David Austin reviews the phase III trial of enalapril for anthracycline-induced cardiotoxicity in lymphoma and breast ...

The ORBITA-COSMIC Trial

10 Feb 2025

Contributed by Lukas

Rasha Al-Lamee and Michael Foley sit down with Mamas Mamas to discuss data on an implantable coronary sinus reducer that can ease symptoms in patients...

The REVIVED-BCIS2 Randomized Trial

04 Feb 2025

Contributed by Lukas

Looking at the REVIVED-BCIS2 results, Divaka Perera and C. Michael Gibson discuss the relationship between myocardial viability, PCI, and outcomes.

Ketogenic Diet and Cardiovascular Risk

15 Jan 2025

Contributed by Lukas

Iulia Iatan talks to C. Michael Gibson about how a low-carbohydrate, high-protein diet can increase plasma lipid levels and cardiovascular risk.

The CLEAR Outcomes Trial

08 Jan 2025

Contributed by Lukas

Steven Nissen and C. Michael Gibson discuss using bempedoic acid to reduce MACE in statin-intolerant patients with high cardiovascular risk.

Inflammatory Risk in Statin-Treated Patients

11 Dec 2024

Contributed by Lukas

Pooling data from the PROMINENT, REDUCE-IT, and STRENGTH trials, Paul Ridker and C. Michael Gibson discuss the residual inflammatory risks for patient...

The BUDAPEST CRT Upgrade Trial

04 Dec 2024

Contributed by Lukas

Béla Merkely and C. Michael Gibson discuss the results of a CRT-D upgrade versus ICD alone for HFrEF patients with right ventricular pacing.

The HEART-FID Trial

20 Nov 2024

Contributed by Lukas

Robert Mentz and C. Michael Gibson discuss the latest trial to address whether iron supplementation, this time with ferric carboxymaltose, improves ou...

The FIRE Study

06 Nov 2024

Contributed by Lukas

Simone Biscaglia and C. Michael Gibson discuss physiology-guided complete revascularization versus culprit-only PCI for elderly patients with acute MI...

The ECLS-SHOCK Trial

23 Oct 2024

Contributed by Lukas

Holger Thiele and C. Michael Gibson discuss the impact of VA-ECMO on patients with acute MI and advanced cardiogenic shock.

The STOPDAPT-3 Trial

09 Oct 2024

Contributed by Lukas

Masahiro Natsuaki and C. Michael Gibson discuss this latest randomized comparison of prasugrel monotherapy and DAPT with aspirin for patients undergoi...

The ILUMIEN IV Trial

02 Oct 2024

Contributed by Lukas

Ziad Ali and C. Michael Gibson take a deeper dive into this comparison of OCT- and angiography-guided PCI.

OCT vs IVUS vs Angiography: A Meta-analysis

11 Sep 2024

Contributed by Lukas

Gregg Stone and C. Michael Gibson discuss an updated meta-analysis addressing intravascular imaging in DES implantation.

The ATTRibute-CM Trial

04 Sep 2024

Contributed by Lukas

Julian Gillmore and C. Michael Gibson discuss the efficacy of acoramidis for patients with transthyretin amyloid cardiomyopathy.

The ADVENT Trial

14 Aug 2024

Contributed by Lukas

Vivek Reddy and C. Michael Gibson compare pulsed field ablation versus thermal ablation for patients with paroxysmal atrial fibrillation.

The ARAMIS Trial

07 Aug 2024

Contributed by Lukas

Mathieu Kerneis and C. Michael Gibson compare outcomes of patients treated with anakinra, a new therapy for acute myocarditis, or placebo.

The NITRATE-CIN Trial

31 Jul 2024

Contributed by Lukas

Dan Jones and C. Michael Gibson discuss whether inorganic nitrate reduces contrast-induced nephropathy after angiography in ACS patients.

The DICTATE-AHF Trial

10 Jul 2024

Contributed by Lukas

Zachary Cox and C. Michael Gibson discuss whether early dapagliflozin initiation is safe and effective for patients with acute heart failure.

The RIGHT Trial

03 Jul 2024

Contributed by Lukas

Shaoping Nie, Gilles Montalescot, and C. Michael Gibson discuss prolonged anticoagulation after primary PCI for patients with MI.

Four-Year Results: The EVOLUT Low Risk Trial

12 Jun 2024

Contributed by Lukas

Michael J. Reardon and C. Michael Gibson discuss the trial's 4-year results in low-surgical-risk patients with severe aortic stenosis randomized to se...

The AGENT IDE Trial

05 Jun 2024

Contributed by Lukas

Robert W. Yeh and C. Michael Gibson discuss the primary outcomes of this eagerly awaited trial comparing the AGENT paclitaxel-coated balloon with conv...

The TRISCEND II Trial

22 May 2024

Contributed by Lukas

Susheel K. Kodali and C. Michael Gibson discuss transcatheter tricuspid valve replacement in patients with severe tricuspid regurgitation.

The VIVA Trial

15 May 2024

Contributed by Lukas

Josep Rodés-Cabau and C. Michael Gibson discuss the benefits of TAVI versus SAVR in patients with severe aortic stenosis and small aortic annuli.

The SELECT Trial

01 May 2024

Contributed by Lukas

A. Michael Lincoff and C. Michael Gibson discuss the cardiovascular impact of semaglutide in patients with overweight or obesity but without diabetes.

The MINT Trial

17 Apr 2024

Contributed by Lukas

Jeffrey Carson and Serge Korjian discuss restrictive versus liberal blood transfusion in patients with MI and anemia.

The ORBITA-2 Trial

03 Apr 2024

Contributed by Lukas

Christopher Rajkumar, Rasha Al-Lamee, and C. Michael Gibson discuss this randomized trial of PCI versus a placebo procedure for stable angina.

The ARIE-HM3 Trial

14 Mar 2024

Contributed by Lukas

Mandeep Mehra and C. Michael Gibson discuss whether or not aspirin is needed for patients with left ventricular assist devices in advanced heart failu...

The AZALEA - TIMI Trial

11 Mar 2024

Contributed by Lukas

Christian T. Ruff and C. Michael Gibson discuss the primary results of a randomized trial testing the efficacy of abelacimab versus rivaroxaban for st...

The heart-1 Trial of VERVE-101

21 Feb 2024

Contributed by Lukas

Andrew Bellinger, Sek Kathiresan, and C. Michael Gibson talk about the phase 1b trial of what investigators hope may be a one-time genetic fix for hyp...

Lepodisiran Phase I Trial

07 Feb 2024

Contributed by Lukas

Steven Nissen and C. Michael Gibson discuss the efficacy and safety of lepodisiran, an extended duration short-interfering RNA meant to reduce lipopro...

CLEAR Outcomes Subanalysis

24 Jan 2024

Contributed by Lukas

Paul Ridker and C. Michael Gibson discuss whether residual inflammatory risk or residual cholesterol risk is a more effective predictor of CV events a...

The AXIOMATIC - SSP Trial

10 Jan 2024

Contributed by Lukas

Mike Sharma and C. Michael Gibson discuss managing acute thromboembolic events in secondary stroke using antithrombotic treatment with factor XIa inhi...

The EBRAVE - AF Trial

03 Jan 2024

Contributed by Lukas

Axel Bauer and C. Michael Gibson talk about whether smartphone-based screening can effectively detect atrial fibrillation in elderly, at-risk patients...

The INVICTUS Trial

07 Dec 2023

Contributed by Lukas

Ganesan Karthikeyan and C. Michael Gibson compare the efficacy of rivaroxaban versus vitamin K agonists for patients with rheumatic heart disease asso...

The FRAME-AMI Trial

04 Oct 2023

Contributed by Lukas

Joo-Yong Hahn and C. Michael Gibson compare FFR with angiography-guided PCI for patients with acute myocardial infarction and multivessel disease.

MASTER DAPT: Long-Term Results

13 Sep 2023

Contributed by Lukas

Marco Valgimigli and C. Michael Gibson discuss the long-term follow-up results from MASTER DAPT, which compared the outcomes of high bleeding risk pat...

Episode 180: The PANTHER Trial

06 Sep 2023

Contributed by Lukas

Marco Valgimigli and C. Michael Gibson discuss the PANTHER trial, which compared P2Y12 inhibitor monotherapy with aspririn monotherapy in patients wit...

Radial vs. Femoral Access for PCI: Meta-Analysis

24 Aug 2023

Contributed by Lukas

Giuseppe Gargiulo and C. Michael Gibson discuss whether the choice of radial or femoral artery access impacts the risk of mortality and major bleeding...

Episode 181: ACT Outpatient and Inpatient Trials

09 Aug 2023

Contributed by Lukas

Sanjit Jolly and C. Michael Gibson discuss if colchicine and rivaroxaban plus aspirin can slow disease progression in patients hospitalized with COVID...

Episode 180: The VALOR-HCM Trial

02 Aug 2023

Contributed by Lukas

Milind Desai and C. Michael Gibson compare the results of mavacamten for severe obstructive hypertropic cardiomyopathy with the typical treatments of ...

Episode 179: The SODIUM-HF Study

12 Jul 2023

Contributed by Lukas

Justin Ezekowitz and C. Michael Gibson look at a sodium-reducing dietary intervention and its effects on patients with HF.

Episode 178: The COMPLETE Trial

05 Jul 2023

Contributed by Lukas

Shamir Mehta and C. Michael Gibson discuss how complete revascularization affects angina-related quality of life in patients with STEMI.

Episode 177: The EDIT-CMD Trial

14 Jun 2023

Contributed by Lukas

Tijn Jansen, Suzette Elias-Smale, and C. Michael Gibson discuss whether diltiazem improves coronary vasomotor dysfunction in patients with angina and ...

Episode 176: The IVVE Trial

24 May 2023

Contributed by Lukas

Mark Loeb and C. Michael Gibson discuss whether the influenza vaccine can reduce adverse vascular events among patients with HF.

Episode 175: The METEORIC-HF Trial

17 May 2023

Contributed by Lukas

Gregory Lewis and C. Michael Gibson discuss how omecamtiv mecarbil affects exercise tolerance in patients with chronic HFrEF.

Episode 174: The DIAMOND Trial

03 May 2023

Contributed by Lukas

Javed Butler and C. Michael Gibson discuss using patiromer to manage hyperkalemia in patients with HFrEF who are taking RAAS inhibitors.

Episode 173: MAVA-LTE: The EXPLORER-LTE Cohort

19 Apr 2023

Contributed by Lukas

Florian Rader and C. Michael Gibson look at cumulative outcomes for patients with obstructive hypertrophic cardiomyopathy treated with mavacamten.

Episode 172:The PACIFIC-AF Study

05 Apr 2023

Contributed by Lukas

Manesh Patel and C. Michael Gibson discuss the results of a phase II trial comparing the safety profiles of asundexian versus apixaban in patients wit...

Episode 171: The PROTECT Trial

22 Mar 2023

Contributed by Lukas

Daniel Sessler and C. Michael Gibson compare myocardial injury rates following mild hypothermia versus aggressive warming during noncardiac surgery.

Episode 170: The ADAPT-TAVR Trial

08 Mar 2023

Contributed by Lukas

Duk-Woo Park and C. Michael Gibson discuss edoxaban vs dual antiplatelet therapy for valve thrombosis and cerebral thromboembolism after TAVI.

Episode 169: The FLAVOUR Trial

01 Mar 2023

Contributed by Lukas

Bon-Kwon Koo and C. Michael Gibson compare the efficacy of FFR-guided and IV ultrasound-guided PCI for coronary artery stenosis.

Episode 168: The GIPS-IV Study

08 Feb 2023

Contributed by Lukas

Marie-Sophie de Koning and C. Michael Gibson discuss whether the use of sodium thiosulfate after STEMI helps preserve cardiac function.

Episode 167: The Spyral HTN-ON MED Pilot Study

01 Feb 2023

Contributed by Lukas

Felix Mahfoud and C. Michael Gibson examine the efficacy of renal denervation for long-term BP reduction in patients taking antihypertensive medicatio...

Episode 166: Chronic Kidney Disease In CANTOS

11 Jan 2023

Contributed by Lukas

Paul Ridker and C. Michael Gibson discuss a secondary analysis from CANTOS looking at residual inflammatory and cholesterol risks based on chronic kid...

Episode 165: The STAR-T/D Trial

04 Jan 2023

Contributed by Lukas

Michael Mack and C. Michael Gibson discuss a novel method for extracting antithrombotics from the blood during CABG.

Episode 164: The LOOP Study for AF Screening

14 Dec 2022

Contributed by Lukas

C. Michael Gibson and Jesper Hastrup Svendsen discuss the use of implantable loop recorders to prevent stroke in AF.

Episode 163: The ENVISAGE-TAVI AF Trial

07 Dec 2022

Contributed by Lukas

C. Michael Gibson and George Dangas discuss edoxaban vs vitamin K antagonists after TAVI in patients with atrial fibrillation.

Episode 162: The FIGARO-DKD Trial

23 Nov 2022

Contributed by Lukas

Episode 162: The FIGARO-DKD Trial by TCTMD

Episode 161: AMULET-IDE: One-Year Outcomes

09 Nov 2022

Contributed by Lukas

C. Michael Gibson and Dhanunjaya Lakkireddy discuss device success and thrombus risk in Amulet versus Watchman for LAA closure.

Episode 160: Shock Classification Gets an Update

02 Nov 2022

Contributed by Lukas

C. Michael Gibson and Timothy Henry discuss key updates to the SCAI SHOCK classifications.

Episode 159: MICHELLE: Rivaroxaban in COVID-19

19 Oct 2022

Contributed by Lukas

C. Michael Gibson and Renato Lopes discuss extended DOAC prophylaxis in medically ill, hospitalized patients with COVID-19.

Episode 158: The RIPCORD 2 Trial

05 Oct 2022

Contributed by Lukas

C. Michael Gibson and Nicholas Curzen discuss whether routine pressure-wire assessment influences the use of coronary angiography for diagnosing chest...

Episode 157: PARTNER 3: Two-Year Economic Outcomes

14 Sep 2022

Contributed by Lukas

C. Michael Gibson and David Cohen discuss cost implications of this TAVI versus SAVR randomized trial.

Episode 156: The IAMI Trial

07 Sep 2022

Contributed by Lukas

C. Michael Gibson and Ole Fröbert discuss the potential for influenza vaccination in post-MI patients.

Episode 155: Two DCBs Go Head to Head in De Novo CAD

25 Aug 2022

Contributed by Lukas

C. Michael Gibson and Wan Azman Wan Ahmad discuss a sirolimus-versus a paclitaxel-coated balloon in de novo coronary lesions.

Episode 154: The EMPEROR-Preserved Trial

10 Aug 2022

Contributed by Lukas

C. Michael Gibson and Stefan Anker discuss the effects of empagliflozin on CV death and HF hospitalizations in patients with HFpEF, with and without d...

Episode 153: iFR-SWEDEHEART at 5 Years

03 Aug 2022

Contributed by Lukas

C. Michael Gibson and Matthias Götberg review 5-year findings after iFR- versus FFR-guided PCI.

Episode 152: PRONOUNCE: Prostate Cancer Drugs and CVD

20 Jul 2022

Contributed by Lukas

Renato Lopes and C. Michael Gibson discuss PRONOUNCE comparing the cardiovascular safety of degarelix vs. leuprolide in patients with advanced prostat...

Episode 151: Stopping Amputation Post-revascularization: Novel Data in Mitigation of Thrombosis Risk

06 Jul 2022

Contributed by Lukas

Desai and Anahita Dua discuss highlights from a CME program on reducing thrombosis risks in patients with PAD post-revascularization. Claim credit: ht...