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The Dr. Hyman Show

Mold, Lyme, Gut Health, and the Mystery of Histamine Intolerance

21 Apr 2025

Transcription

What is Histamine Intolerance?

1516.798 - 1545.684 Dr. Mark Hyman

heart palpitations dizziness vertigo feelings anxiety so sometimes people will feel more anxious when their histamine levels are high chronic fatigue and so you know histamine and get a lot of nasal congestion right and sometimes even asthma symptoms and absolutely right absolutely brain fog and everything right so it got me dismissed as you know the people don't put the dots together and the doctors don't often put the dots together and

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1546.412 - 1550.89 Dr. Mark Hyman

And these symptoms are often seen as disparate or not connected, but they're all really connected, right?

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1551.519 - 1572.411 Dr. Mark Hyman

They are right. They are. And it is, you know, to be honest, I've often not put the dots together. Right. So it is it is not always easy. We're always like, oh, this person has headaches. Why are they getting headaches or they're having digestive issues? And and then all of a sudden you go, oh, this is all related. And I've got to be thinking about histamine.

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1572.651 - 1597.209 Dr. Mark Hyman

And and so, you know, we've learned a lot over the years to to be able to help people as well. Um, so I think of mast cell activation syndrome, it's more systemic, there can be a lot more things going on. And, and, and, you know, when we say the word histamine intolerance, we're really thinking a lot about that, you know, that reaction that happens from eating a food and, and

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1597.935 - 1617.098 Dr. Mark Hyman

and that histamine reaction or that histamine imbalance that occurs after a meal where there's just too much histamine around and the body's not able to break it down. But you know what, it's often a clinical diagnosis, right? So it's often based on looking at that person's story and understanding

1618.551 - 1631.277 Dr. Mark Hyman

you know, really understanding their timeline and what their symptoms are and looking for those inner connections that can really help us to determine if this is what's going on for them because the testing is imperfect.

1632.098 - 1645.284 Dr. Mark Hyman

Yeah, that's right. I mean, like in terms of traditional medicine, what would be the traditional approach to diagnostics, testing, and then treatment? And then let's sort of talk about how we would approach this from a functional medicine perspective.

1645.791 - 1675.201 Dr. Mark Hyman

Right. So, you know, you can measure histamine levels, right? So whether you can measure histamine levels in the blood, so you can measure something called histamine and tryptase in the blood. And you can measure histamine in the urine. It's a methyl histamine urine test that's done. And that test is often done both functionally and conventionally. And it can be helpful if the levels are high.

1675.562 - 1693.746 Dr. Mark Hyman

So if the levels are high, you go, oh, this person has an issue with histamine. But what's a problem with this test is that the levels fluctuate a lot during the day and depending on what you just ate and the amount of food you ate and how we'll talk about this later. It's not super reliable, right?

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