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The Dr. Tyna Show

Microdosing GLP1s Has Gone Mainstream | Quick + Dirty

24 Mar 2025

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EP. 201: On this quick-and-dirty solo episode, I'm diving into a brand-new article just published in Diabetes Care (March 2025, Vol. 48): "One Size Does Not Fit All: Understanding Microdosing Semaglutide for Diabetes and Multi-Dose Pens." This opinion piece by respected endocrinologists signals a massive shift in the conversation—one I’ve been screaming from the rooftops for over a year. While I’m not claiming credit (ok maybe a little), I am thrilled to see microdosing GLP-1s being acknowledged by mainstream medicine… even if they’re still getting a lot of it, well, OFF. Let’s be clear: microdosing  was NEVER meant to be a weight loss strategy, even thought that’s what everyone seems to think it’s for. And if you’re NOT using these drugs without a full metabolic support plan—protein, lifting, hormones, insulin sensitivity—you’re setting yourself (or your patients) up to fail. Topics Discussed:  → What the pen-click method is and why it's a game-changer → Why splitting up a full dose is not microdosing (despite what TikTok tells you) → The difference between low-dosing, standard dosing, and true microdosing → Why microdosing isn’t a long-term solution for weight loss or type 2 diabetes → How this concept can support tolerability, access, and personalized care → Why most “microdosing” marketing is just sloppy semantics → The real clinical rationale behind true microdosing → How to use GLP-1s intelligently as part of a broader metabolic protocol I break it all down in this episode, and if you want to go deeper, grab my free 4-part video series at drtyna.com/ozempicuncovered — it’ll walk you straight into the most comprehensive GLP-1 course available for clinicians and smart self-healers alike. Sponsored By:  → Qualia | Go to qualialife.com/DRTYNA and use code DRTYNA at checkout for up to 15% off your purchase. → LVLUP | Head over to LVLUPHealth.com and use code DRTYNA at checkout to get 20% off your order sitewide.  → Manukora | Head to manukora.com/DRTYNA to get $25 off the Starter Kit, which comes with an MGO 850+ Manuka Honey jar On This Episode We Cover: → 00:00:00 - Introduction & Milestone → 00:02:45 - Ozempic: Weight Loss & Dosing → 00:10:28 - Semaglutide Research Highlights → 00:14:12 - Pen-Click Microdosing Method → 00:16:06 - GLP-1s in Treatment Plans Further Listening:  → GLP1s Uncovered FREE 4 Part Video Series  Show Links:  → One Size Does Not Fit All: Understanding Microdosing Semaglutide for Diabetes in Multidose Pens Disclaimer: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.

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Full Episode

1.121 - 24.03 Tina Moore

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58.753 - 75.579 Tina Moore

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75.899 - 99.146 Tina Moore

And if you want to deep dive into the science and hear more about this formulation, check out episode 200 of the Dr. Tina show, where I was honored to interview the founder and formulator of Level Up Health, Kyle Vanderfleet. On this episode of The Dr. Tina Show, this is gonna be a quick and dirty episode. It is my 201st episode of this show. So I'm very excited and thank you for being here.

99.206 - 120.616 Tina Moore

If you're new, thank you for joining. If you have been here the whole time, thank you so much for being on this journey with me. I can't believe it's been 200 episodes. What a crazy time. I have a very exciting article to report. So we're going to break this down today. This just came out March 2025. It is from the Journal of Diabetes Care. It is volume 48.

121.277 - 144.15 Tina Moore

You can access it yourself for free on the internet. It's called One Size Does Not Fit All, Understanding Microdosing, Semaglutide or Semaglutide for Diabetes in Multidose Pens. I'm really excited that this is out. This is in a medical journal, a renowned, respected medical journal. It was written by respected endocrinologists. And this is an opinion piece.

144.19 - 162.373 Tina Moore

This isn't a medical study, but it is in a medical journal. So we can talk about it. I'm not sure that I can take any credit for this whatsoever, but I feel like I've had a huge part in this conversation. I took the heat early on when nobody else was willing to have this discussion.

162.933 - 181.945 Tina Moore

Now, before I get into this, I do want to say this was never meant to be a diabetes treatment, nor was it ever meant to be a weight loss strategy. And I talk about that in depth inside of my course. I have a big course on the topic. It's for clinicians. It's for practitioners. I also let the general public in. I've made sure that it's friendly for both groups.

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