The Dr. Tyna Show
Tirzepatide + Metabolic Health: What the Latest Study Really Shows | Solo
18 Apr 2025
EP. 207: A new study on tirzepatide just dropped, and some obesity experts claim it confirms that the drug works only by reducing calories. After reading the full paper myself, I’ve got a different take. In this episode, I unpack what the study actually shows—like how tirzepatide increases fat oxidation without impacting metabolic adaptation—and why the “calories in, calories out” story doesn’t tell the whole truth. There’s more going on here, and you deserve the full picture. Topics Covered: →Does tirzepatide help with metabolic health beyond calorie restriction leading to weight loss? →How does it affect metabolic adaptation in people with obesity? →Can it boost fat oxidation? →Is the “calories in, calories out” model outdated for GLP-1s? →What does this mean for long-term metabolic health? Sponsored By: → Qualia | Go to qualialife.com/DRTYNA for up to 50% off your purchase and use code DRTYNA for an additional 15% →Sundays | As a Listener of The Dr Tyna Show, you can Get 40% off your first order of Sundays. Go to sundaysfordogs.com/DRTYNA and use code DRTYNA at checkout. →Liver Love | Go to=https://store.drtyna.com/products/liverlove Use code DRTYNASHOW at checkout to save. →LMNT | Get your free Sample Pack with any LMNT purchase atdrinkLMNT.com/drtyna →BIOptimizers | For an exclusive offer on MassZymes go to Bioptimizers.com/DRTYNAand use promo code DRTYNA On This Episode We Cover: → 00:00:00 – Introduction → 00:02:44 – Obesity study on GLP1s and weight loss → 00:04:21 – Calories in vs. calories out → 00:05:44 – Resting metabolic rate → 00:09:25 – Metabolic adaptation during dieting → 00:12:11 – Tirzepatide dosing in clinical studies → 00:15:49 – Maintaining weight loss → 00:18:15 – GLP1s & increased fat oxidation → 00:19:14 – GLP1 microdosing myths → 00:26:06 – Metabolic rate drops vs. metabolic improvements → 00:29:51 – Lessons from the Biggest Loser study → 00:34:20 – Study Comparation → 00:35:25 – Weight loss, inflammation, and aging → 00:36:35 – Health autonomy → 00:40:23 – Caloric restriction and the CALERIE study Studies Mentioned: → Tirzepatide Did Not Impact Metabolic Adaptation In People With Obesity, But Increased Fat Oxidation → Persistent Metabolic Adaptation 6 Years After The Biggest Loser Competition → Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE) Show Links → GLP-1s Done Right University → Dr. Tyna’s Strength Corner → Metabolic Revamp Toolkit + Masterclass Further Listening: → GLP1s Uncovered (Free Class) → EP. 202 | The Fight for Affordable GLP1s & the Truth About Big Pharma | Dave Knapp Disclaimer: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.
Full Episode
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I am very excited about this episode today. A recent study has come across my desk that I wanted to share with you. I was first alerted about it by some of the big obesity docs that I follow on social media and they came out and had one opinion about the paper and So I looked up the paper immediately, of course, and found that you had to access it behind a paywall and it was quite long.
So I went ahead and paid for the article so that I could read the whole thing because the title is a little misleading and the key highlights are a little bit misleading. And so I wanted to make sure that I read the whole thing, digested it, worked with the information, and I'm going to present it as I understand it. Because no disrespect to these docs. I respect them very much.
They're obesity docs. I'm not. But I do understand metabolic health really well. And I don't think they're getting the whole story straight. So let's jump in. All right, so first of all, here's the study. Terzepatide did not impact metabolic adaptation in people with obesity, but increased fat oxidation. That's the title. It's in Cell Metabolism, Clinical and Translational Report.
Just came out May 2025. Here it is, all right?
see if we can focus in on that my camera wants to be picky so what did this study show i'm just going to read the first part first page so you guys can gleam what i think most people are gleaming from it first they looked at pre-clinical mouse experiments and then they did a phase one clinical study on 55 humans very small 55 humans doesn't tell us a tremendous amount but hey it's it's what we got
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