The Lancet Gastroenterology & Hepatology in conversation with
Episodes
Aleksander Krag on the utility of PEth for subclassifying individuals at risk of steatotic liver disease
23 Feb 2026
Contributed by Lukas
Steatotic liver disease labels hinge on alcohol intake, but self-report is often inaccurate. In this episode, Aleksander Krag (Odense University Hospi...
Dina Kao on a trial of lyophilised sterile faecal filtrate versus lyophilised conventional donor stool for recurrent Clostridiodes difficile infection
28 Nov 2025
Contributed by Lukas
Can bacteria-free, sterile faecal filtrate match conventional faecal microbiota transplantation for recurrent C difficile infection? Dina Kao (Univers...
Premysl Bercik on a double-blind crossover trial of gluten and wheat in IBS
20 Nov 2025
Contributed by Lukas
Do wheat or gluten trigger IBS symptoms? We spoke to Premysl Bercik about a randomised, double-blind, sham-controlled crossover trial that challenged...
Julia Mayerle on the validation of plasma multimetabolite signatures for patients at risk of or with suspected pancreatic ductal adenocarcinoma
19 Jun 2025
Contributed by Lukas
Can a multi-metabolite blood test improve early pancreatic cancer detection? We spoke to Julia Mayerle about the METAPAC study, which sought to valida...
Salvatore Piano on the global epidemiology of acute kidney injury in hospitalised patients with decompensated cirrhosis
09 Apr 2025
Contributed by Lukas
How does acute kidney injury presentation and management differ globally for patients hospitalised with cirrhosis? We spoke to Salvatore Piano, corre...
John Chia on the ASCOLT trial of adjuvant aspirin for colorectal cancer
06 Mar 2025
Contributed by Lukas
John Chia discusses the results of the ASCOLT trial, which explored the effect of aspirin after completion of standard adjuvant therapy for patients w...
Hannes Hagström on screening for advanced liver fibrosis alongside retina scanning in people with type 2 diabetes
10 Jan 2025
Contributed by Lukas
Hannes Hagström discusses a study investigating the feasibility of screening for advanced liver fibrosis alongside retina scanning in people with typ...
Cathy Lu on intestinal ultrasound for assessing and monitoring Crohn's disease small bowel strictures
12 Dec 2024
Contributed by Lukas
Cathy Lu (University of Calgary) discusses a consensus statement on the use of intestinal ultrasound for assessing and monitoring small bowel strictur...
Peter De Cruz on the PREDICT-UC trial of intensified versus standard dose infliximab for steroid-refractory acute severe ulcerative colitis
06 Nov 2024
Contributed by Lukas
Peter De Cruz (University of Melbourne) discusses the PREDICT-UC trial of intensified versus standard dose infliximab induction therapy for steroid-re...
Shahida Din and Beatriz Gros on the harms associated with receiving placebo in trials of drugs for inflammatory bowel disease
01 Nov 2024
Contributed by Lukas
Shahida Din (Western General Hospital, Edinburgh) and Beatriz Gros (Reina Sofía University Hospital, Cordoba) discuss two new papers on the harms ass...
Arndt Vogel on the NALIRICC trial of nanoliposomal irinotecan in pretreated advanced biliary tract cancer
31 Jul 2024
Contributed by Lukas
Arndt Vogel (Toronto General Hospital) discusses the NALIRICC trial of nanoliposomal irinotecan added to fluorouracil plus leucovorin in patients with...
Nancy Baxter on the duration of colorectal cancer risk reduction with a complete colonoscopy
01 Jul 2024
Contributed by Lukas
Nancy Baxter (University of Melbourne) discusses a population-based study on the duration of risk reduction in colorectal cancer incidence and mortali...
Sanna Nybacka and Magnus Simrén on a trial of low FODMAP diets versus low carbohydrate diets in IBS
17 May 2024
Contributed by Lukas
Sanna Nybacka and Magnus Simrén (University of Gothenburg) discuss the CARIBS randomised controlled trial of a low FODMAP diet versus a low-carbohydr...
Nuru Noor on the PROFILE trial of biomarker-stratified treatment in newly diagnosed Crohn's disease
07 May 2024
Contributed by Lukas
Nuru Noor (University of Cambridge) discusses the PROFILE trial of biomarker-stratified treatment strategies in people with newly diagnosed Crohn&apos...
Yusuke Shimakawa on a simple score for hepatitis B treatment eligibility in Africa
22 Apr 2024
Contributed by Lukas
Yusuke Shimakawa (Institut Pasteur) discusses the development and evaluation of a simple score for hepatitis B treatment eligibility in Africa.Read th...
Mads Israelsen on validating the new steatotic liver disease nomenclature in people with excessive alcohol intake
12 Mar 2024
Contributed by Lukas
Mads Israelsen (Odense University Hospital) discusses a study to validate the new nomenclature of steatotic liver disease in patients with a history o...
Louise Dye on the role of expectancy and gluten in non-coeliac gluten sensitivity
01 Mar 2024
Contributed by Lukas
Louise Dye (University of Leeds) discusses a trial exploring the role of expectancy and gluten ingestion on symptoms in people with non-coeliac gluten...
Tzu-Chan Hong on the primary antibiotic resistance of Helicobacter pylori in the Asia-Pacific region
19 Dec 2023
Contributed by Lukas
Tzu-Chan Hong (National Taiwan University Cancer Centre) discusses a systematic review and meta-analysis on primary antibiotic resistance of Helicobac...
Sarah Moen on metachronous colorectal cancer risk according to Lynch syndrome pathogenic variant after colectomy
29 Nov 2023
Contributed by Lukas
Sarah Moen (Erasmus University Medical Center) discusses a retrospective cohort study examining the risk of metachronous colorectal cancer after parti...
Anna Emilie Kann on the causes of mortality in patients with alcohol-related liver disease
12 Oct 2023
Contributed by Lukas
Anna Emilie Kann (Zealand University Hospital, Denmark) discusses a population-based study done in Denmark exploring the causes of mortality in pati...
Robert Krouse on surgical versus non-surgical management of malignant bowel obstruction
13 Sep 2023
Contributed by Lukas
Robert Krouse (University of Pennsylvania) discusses the pragmatic S1316 trial of surgical versus non-surgical management for patients with malignant ...
Marc Rothenberg on a trial of benralizumab in eosinophilic gastritis
10 Aug 2023
Contributed by Lukas
Marc Rothenberg (University of Cincinnati College of Medicine) discusses a new trial assessing the efficacy and safety of benralizumab in patients wit...
Michael Pavlides on non-invasive tests for predicting clinical outcomes in non-alcoholic fatty liver disease
12 Jul 2023
Contributed by Lukas
Michael Pavlides (University of Oxford) discusses work by the LITMUS Consortium on the prognostic performance of non-invasive tests in patients with n...
Jasmohan Bajaj on global disparities in mortality and liver transplantation in hospitalised patients with cirrhosis
07 Jun 2023
Contributed by Lukas
Jasmohan Bajaj (Virginia Commonwealth University and Central Virginia Veterans Healthcare System, Richmond, VA, USA), on behalf of the CLEARED Consort...
Adelina Artenie on the incidence of HIV and HCV in people who inject drugs
10 May 2023
Contributed by Lukas
Adelina Artenie (University of Bristol, UK) discusses a systematic review and meta-analysis exploring the incidence of HIV and HCV among people who in...
Johan Burisch on the costs of inflammatory bowel disease in high-income settings
12 Apr 2023
Contributed by Lukas
Johan Burisch (Copenhagen University Hospital, Denmark) discusses the findings and recommendations of The Lancet Gastroenterology & Hepatology Com...
Edouard Louis on the SPARE trial of infliximab or immunosuppressant withdrawal in Crohn’s disease
08 Feb 2023
Contributed by Lukas
Edouard Louis (University Hospital CHU of Liège) discusses the SPARE randomised controlled trial of infliximab or concomitant immunosuppressant withd...
Paula Ghaneh on the ESPAC5 trial of neoadjuvant therapy in borderline resectable pancreatic cancer
23 Jan 2023
Contributed by Lukas
Paula Ghaneh (University of Liverpool) discusses the ESPAC5 randomised controlled trial of short-course neoadjuvant therapy compared with immediate su...
Dan Turner on vedolizumab in children with IBD
06 Jan 2023
Contributed by Lukas
Dan Turner (Shaare Zedek Medical Center) discusses the VEDOKIDS study on the safety, effectiveness, and dosing of vedolizumab in children with IBD.Rea...
Simon Baunwall on faecal microbiota transplantation for first or second Clostridioides difficile infection
09 Nov 2022
Contributed by Lukas
Simon Baunwall (Aarhus University Hospital) discusses the EarlyFMT trial, a randomized placebo-controlled trial of faecal microbiota transplantation f...
James Alexander on immune responses to COVID-19 vaccination in patients with IBD
05 Oct 2022
Contributed by Lukas
James Alexander (Imperial College London) discusses the latest findings from the VIP case-control study, which is investigating COVID-19 vaccine immun...
Filip Knop on liraglutide for bile acid diarrhoea
07 Sep 2022
Contributed by Lukas
Filip Knop (University of Copenhagen) discusses a trial of liraglutide versus colesevelam for the treatment of bile acid diarrhoea.Read the full artic...
Edward Kim on radiation segmentectomy for unresectable very early to early stage hepatocellular carcinoma
04 Aug 2022
Contributed by Lukas
Edward Kim (Icahn School of Medicine at Mount Sinai) discusses the single-arm RASER study of radiation segmentectomy for patients with unresectable ve...
Joep Ijspeert on serrated polyp detection and risk of interval post-colonoscopy colorectal cancer
06 Jul 2022
Contributed by Lukas
Joep Ijspeert (Amsterdam University Medical Center) discusses a population-based study exploring the detection of proximal serrated polyps and interva...
Elise Meima-van Praag on surgical closure for Crohn’s disease perianal fistulas
14 Jun 2022
Contributed by Lukas
Elise Meima-van Praag (Amsterdam University Medical Centre) discusses the PISA-II trial, investigating short-term anti-TNF therapy with surgical closu...
Juan Pablo Arab on NAFLD public health policies in the Americas
09 May 2022
Contributed by Lukas
Juan Pablo Arab (Catholic University of Chile) discusses the current burden of NAFLD and the landscape of public health policies related to the diseas...
Sarah Blach on hepatitis C virus epidemiology
06 Apr 2022
Contributed by Lukas
Sarah Blach (CDA Foundation) summarises the latest analysis of global hepatitis C virus epidemiology and cascade of care by the Polaris Observatory HC...
Sunil Solomon on a minimal monitoring approach for hepatitis C virus infection
23 Mar 2022
Contributed by Lukas
Sunil Solomon (Johns Hopkins University) discusses a study of a minimal monitoring approach for treating patients with hepatitis C virus infection.Rea...
Rupert Leong on oral faecal microbiota transplantation in ulcerative colitis
09 Mar 2022
Contributed by Lukas
Rupert Leong (University of Sydney) discusses a new double-blind, randomised, placebo-controlled trial of oral faecal microbiota transplantation for p...
Swati Patel on early-onset colorectal cancer
09 Feb 2022
Contributed by Lukas
Swati Patel (University of Colorado Anschutz Medical Center) discusses the epidemiology, clinical features, biology, risk factors, and opportunities f...
Emilie Breekveldt on FIT-based screening for colorectal cancer in the Netherlands
10 Dec 2021
Contributed by Lukas
Emilie Breekveldt (Erasmus Medical Center, Netherlands) discusses a new analysis of the faecal immunochemical testing-based colorectal screening progr...
Wendy Spearman on non-alcoholic fatty liver disease in sub-Saharan Africa
11 Nov 2021
Contributed by Lukas
Wendy Spearman (University of Cape Town) discusses a Series on the emergence of non-alcoholic fatty liver disease in Sub-Saharan Africa and the challe...
Tim Vanuytsel on spore-forming probiotics in functional dyspepsia
09 Sep 2021
Contributed by Lukas
Tim Vanuytsel (University of Leuven) discusses a new trial of spore-forming probiotics in functional dyspepsia.Read the full article:https://www.thela...
Raymond Henderson on the economic burden of colorectal cancer
12 Aug 2021
Contributed by Lukas
Raymond Henderson (Queen’s University Belfast) discusses a new analysis of the economic burden of colorectal cancer in Europe.Read the full article:...
Sigurður Ólafsson on eliminating hepatitis C in Iceland
22 Jun 2021
Contributed by Lukas
Sigurður Ólafsson (Landspitali University Hospital) discusses newly published results from the nationwide programme to eliminate hepatitis C virus i...
Caroline Ovadia on intrahepatic cholestasis of pregnancy
03 Jun 2021
Contributed by Lukas
Caroline Ovadia (King’s College London) discusses an individual participant data meta-analysis on the treatment of intrahepatic cholestasis of pregn...
Matthew Akiyama on hepatitis C in prisons
12 Apr 2021
Contributed by Lukas
Matthew Akiyama (Montefiore Medical Center and Albert Einstein College of Medicine, USA) discusses a Review on hepatitis C elimination among people in...
Monika Sarkar on reproductive health in women with liver disease
11 Mar 2021
Contributed by Lukas
Monika Sarkar (University of California San Francisco, USA) discusses her Comment on reproductive health in women with chronic liver disease.Read the ...