📢 Become an Insider: https://benbikman.com📢 Ben’s LPS/Leaky Gut Recommendations: https://us.fullscript.com/plans/insuliniq-leaky-gut-recommendations📢 Ask Dr. Bikman’s Digital Mind (multilingual):https://benbikman.com/ben-bikmans-digital-ai-mind📢 Dr. Bikman’s Community & Coaching Site, Insulin IQ: https://insuliniq.comIn this Metabolic Classroom lecture, Ben explains how lipopolysaccharides (LPS)—toxic molecules from gram-negative gut bacteria—can escape into the bloodstream through a compromised intestinal lining, triggering chronic low-grade inflammation and insulin resistance.Dr. Bikman breaks down the roles of tight junction proteins like ZO-1, occludin, and claudins, and explains how the signaling molecule zonulin disrupts these junctions. Zonulin release is often triggered by dysbiosis and dietary components like gluten and fructose.He also highlights how LPS-induced inflammation impairs insulin signaling and promotes ceramide production, contributing to liver fat accumulation and systemic insulin resistance.Ben offers practical, evidence-based strategies to maintain gut barrier integrity and reduce LPS absorption—these include:- apple cider vinegar- spore-forming probiotics (especially Bacillus subtilis)- prebiotic fibers (like FOS and XOS)- and omega-3-rich foods or supplementsDr. Bikman ends with dietary and lifestyle takeaways to protect gut health and metabolic function.Show Notes/References:For complete show notes and references, we invite you to become an Insider subscriber or member. You’ll enjoy real-time, livestream Metabolic Classroom access which includes live Q&A with Ben after the lecture, unlimited access to Dr. Bikman’s Digital Mind, ad-free podcast episodes, show notes and references, and online, live Office Hours access with Ben. It also includes Ben’s Weekly Research Review Podcast. Learn more: https://www.benbikman.comNOTE: The information presented is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Dr. Bikman is not a clinician—and, he is not your doctor. Always seek the advice of your own qualified health providers with questions you may have regarding medical conditions. Hosted on Acast. See acast.com/privacy for more information.

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