Dr Fede Amati
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What is the main topic discussed in this episode?
Hello and welcome to The Midpoint. And it is a very warm welcome back to the wonderful medical scientist and clinical nutritionist, Dr. Federica Amati. She's back with a timely new book, The Appetite Reset. And the core of the book is the idea that hunger is not a test of willpower. It is indeed a biological function. And this, of course, comes out as the use of GLP-1s are ever more mainstream, ever more popular. And the conversation around their long-term use and how to get off them without piling on the weight is also getting louder. She looks at why jabs alone are not enough and why you should be preparing before you even start using them. And of course, if you don't want to use a GLP-1, the book is for you because it aims to help you reduce food noise, something people talk about when they find it really difficult to lose weight and how you can improve that idea of being fully sated.
There is lots to talk about. You've also sent in a load of brilliant questions, so I'm going to put those to her too. So let's go meet Dr. Federica Amati. Federica Amati, it's so great to have you back on The Midpoint. And you have this new book, The Appetite Reset. And I'm intrigued to know when you realised this book was necessary with the conversation and the noise around GLP-1s.
What is the core idea behind Dr. Fede Amati's book, The Appetite Reset?
Yeah, I think it was around autumn last year, actually, so quite recently. But the conversation had really picked up. I was asked to contribute to a documentary for the BBC two, three years ago when it first started. And a lot of the predictions we made then started coming true about... how people were going to come off it and potentially be in worse shape than when they started. And all of these stories started to come up, you know, lean mass loss and side effects.
How do GLP-1 medications change the conversation around weight loss?
And I just thought, actually, I have quite a lot of patients that I've looked after with my clinical team, Well-Founded Health. They're a group of doctors and we work together. together and it's exactly how you should take these drugs right so with all the care and even then it's complicated and each patient's very different and so I just thought actually this is a you know I always try to make my books useful Gabby so that people can actually take something from them and improve their lives and I thought this would be quite useful because we know that the stat that did it for me was that 99% of people are accessing these drugs outside of a healthcare setting
99%?
Yeah, depending on which estimate. Some say over 95, but it's definitely sort of in the 90s.
So they're not getting any support before they go on them, during their usage, maybe ticking a box on a website or something, and then coming off, which is obviously hugely important. Exactly.
Yes, and now we know that 50 to 60% of people come off within a year. And this is for people whose prescriptions are due to obesity or type 2 diabetes. So this is for the people who are taking the drugs as intended.
Why is it important to prepare before starting GLP-1 medications?
Even they're coming, sort of stopping within a year. So there's a real need to help support people through this time. And as I started writing the book, which was really designed to be a companion to anyone who is thinking about taking the drugs or on them or coming off them, I started to realize actually the science of appetite is fascinating. And it's not always explained or taught, even at medical school. So as you know, I teach medical students about nutrition. And I was like, we don't actually teach that much about how appetite regulation works, the hormones involved, you know, how it all functions.
What does 'food noise' mean and how can it affect weight loss?
So in the end, the first half of the book is actually just the physiology of hunger and appetite.
Which is wonderful. it's relevant to somebody who isn't going on GLP-1s or thinking of going on them because they can almost if they understand what appetite is and how it works you're hoping that they then can control that with their diet
Yes. The hope is that if we have a better understanding and appreciation of how the system is set up and it is actually set up for us to succeed, like biology is trying to help us out here, then we can appreciate it better, realise that we are in a situation where the environment we live in is stacked against us.
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Chapters
7 chapters
1
What is the main topic discussed in this episode?
0:03–1:15
2
What is the core idea behind Dr. Fede Amati's book, The Appetite Reset?
1:15–1:44
3
How do GLP-1 medications change the conversation around weight loss?
1:44–2:48
4
Why is it important to prepare before starting GLP-1 medications?
2:48–3:23
5
What does 'food noise' mean and how can it affect weight loss?
3:23–13:46
6
How can understanding appetite physiology improve eating habits?
13:46–19:08
7
What role do nutrients play in appetite regulation?
19:08–39:25