In Episode 54 of the Total Knee Success Podcast, Michelle examines stem cell injections for knee arthritis and explains what these treatments actually contain, how they are regulated, and what current research suggests about their effectiveness. The episode separates regenerative medicine marketing from evidence‑based expectations and helps listeners understand the difference between symptom relief and structural joint restoration. Listeners also learn about evaluating biologic injection claims and prepare for informed treatment decisions before knee replacement.What will you do before surgery? You need a clear checklist so you know exactly what to prepare, what to expect, and how to set yourself up for a smoother first week after surgery. totalkneesuccess.kit.com/free2weeklaunchThe Knee Replacement Game Plantotalkneesuccess.comMedical Disclaimer: This podcast is for educational purposes only and does not constitute medical advice. The content is not intended to replace individualized medical guidance, diagnosis, or treatment. Always consult your surgeon, physical therapist, or other qualified healthcare provider regarding your specific condition, surgical decisions, and rehabilitation plan.Amazon Affiliate Disclaimer: Some resources mentioned in this podcast may include Amazon affiliate links. If you choose to purchase through these links, the podcast may earn a small commission at no additional cost to you.Evidence-Based Content Statement: All information presented in this episode is grounded in peer-reviewed research, published clinical guidelines, and current best practices in orthopedic surgery and rehabilitation.Music Licensing Statement: Intro and outro music for the Total Knee Success Podcast is licensed for commercial use. Editing and production for this episode were completed using Descript.ReferencesGränicher P, Mulder L, Lenssen T, et al. Prehabilitation improves knee functioning before and within the first year after total knee arthroplasty: a systematic review with meta‑analysis. J Orthop Sports Phys Ther. 2022;52(11):709‑725.Orange GM, Hince DA, Jones M, et al. Physical function following total knee arthroplasty for osteoarthritis: a longitudinal systematic review with meta‑analysis. J Orthop Sports Phys Ther. 2025;55(1):1‑14.Goff AJ, Donaldson A, de Oliveira Silva D, Crossley KM, Barton CJ. Physical therapists prioritize providing education about exercise therapy and dispelling misconceptions for people with knee osteoarthritis. J Orthop Sports Phys Ther. 2022;52(9):607‑616.Jo CH, Chai JW, Jeong EC, et al. Intra‑articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof‑of‑concept clinical trial. Stem Cells. 2014;32(5):1254‑1266.Lamo‑Espinosa JM, Mora G, Blanco JF, et al. Intra‑articular injection of two different doses of autologous bone marrow mesenchymal stem cells versus hyaluronic acid for knee osteoarthritis: randomized controlled trial. Stem Cells Transl Med. 2016;5(10):1288‑1296.Pers YM, Rackwitz L, Ferreira R, et al. Adipose mesenchymal stromal cell‑based therapy for severe osteoarthritis of the knee: a phase I dose‑escalation trial. Stem Cells Transl Med. 2016;5(7):847‑856.

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