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This Podcast Will Kill You

Special Episode: Alexandra Sifferlin & The Elusive Body

02 Jun 2026

Transcription

Transcript generated automatically by AI and may contain errors.

Chapter 1: What is the main topic discussed in this episode?

1.516 - 7.848 Erin Welsh

This is exactly right.

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8.028 - 21.232 Unknown

Ten, ten shots fired in City Hall building. How could this have happened in City Hall? Somebody tell me that. A shocking public murder. This was one of the most dramatic events that really ever happened in New York City politics.

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21.493 - 24.418 Erin Welsh

I screamed, get down, get down. Those are shots.

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25.225 - 45.126 Unknown

A tragedy that's now forgotten. And a mystery. That may or may not have been political. That may have been about sex. Listen to Rorschach, Murder at City Hall on the iHeartRadio app, Apple Podcasts, or wherever you get your podcasts. You know the famous author Roald Dahl. He thought up Willy Wonka and the BFG.

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Chapter 2: How does Alexandra Sifferlin's personal journey influence her writing?

45.706 - 55.928 Unknown

But did you know he was a spy? Neither did I. You can hear all about his wildlife story in the podcast, The Secret World of Roald Dahl. All episodes are out now.

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56.269 - 61.176 Erin Welsh

Was this before he wrote his stories? It must have been. What? Okay, I don't think that's true.

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61.517 - 70.47 Unknown

I'm telling you, the guy was a spy. Binge all 10 episodes of The Secret World of Roald Dahl now on the iHeartRadio app, Apple Podcasts, or wherever you get your podcasts.

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71.632 - 79.119 Erin Welsh

When a group of women discover they've all dated the same prolific con artist, they take matters into their own hands.

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79.68 - 81.962 Unknown

I vowed I will be his last target.

82.262 - 83.924 Erin Welsh

He is not going to get away with this.

84.344 - 86.286 Unknown

He's going to get what he deserves.

86.306 - 87.707 Erin Welsh

We always say that.

Chapter 3: What are the different types of diagnostic errors and their prevalence?

88.108 - 98.938 Erin Welsh

Trust your girlfriends. Listen to The Girlfriends, Trust Me Babe, on the iHeartRadio app, Apple Podcasts, or wherever you get your podcasts.

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146.371 - 174.311 Erin Welsh

Hi, I'm Erin Welsh, and this is This Podcast Will Kill You. You're listening to the latest episode in the TPWKY Book Club series. This is the series where I get to chat with authors of popular science and medicine books about their latest work and ask them a and what the future might hold. We've covered some incredibly wide-ranging topics. There's truly something for everyone out there.

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174.351 - 190.696 Erin Welsh

If you'd like to take a look at all of the books we've featured in the past, as well as get a sneak peek into the books that we'll be featuring in upcoming episodes, head over to our website thispodcastwillkillyou.com. There, under the Extras tab, you'll find a link to our bookshop.org affiliate page.

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191.177 - 209.27 Erin Welsh

Clicking on that will get you to a bunch of TPWKY-related book lists, including one for this book club and one for the Kids Book Club, which Erin Updike posts on our socials. So if you're not already following us there, you should be. I'm always updating these lists, so be sure to check in regularly.

Chapter 4: How does technology impact the diagnostic process?

209.29 - 229.238 Erin Welsh

If you have book suggestions, topic suggestions, a first-hand account, or anything else you'd like to share, the best way to get in touch is through the Contact Us form on our website or through the first-hand account form. Two last things before I can introduce this week's book. and that is to please rate, review, and subscribe. It's a big help.

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229.859 - 253.104 Erin Welsh

And finally, you can now find full videos of most of our newest episodes on YouTube. Make sure you're subscribed to the Exactly Right YouTube channel so you never miss a new episode drop. Every year, millions of people will make an appointment with their doctor to try to make sense of a set of symptoms they're experiencing. What happens next can fall into several different categories.

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253.985 - 271.685 Erin Welsh

Number one, they are given the correct diagnosis or start on a path that will lead to the correct diagnosis. Number two, they are given the wrong diagnosis. Or number three, they get no diagnosis at all, despite needing one. Most of us experience the first option.

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272.045 - 287.121 Erin Welsh

After all, we are taught that science and medicine have the answers, so of course that's where we turn when we have questions about our health. But for millions of people, that initial visit does not result in a correct diagnosis, nor does the second or the third.

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287.181 - 298.232 Erin Welsh

In fact, many people wait years for an answer, years marked by the emotional and physical pain that comes with being considered unexplainable in the eyes of medicine.

Chapter 5: What role does the physical exam play in diagnosis?

298.212 - 320.625 Erin Welsh

The vast extent and profound impact of this issue has been understudied, but this week's book seeks to correct that oversight. In The Elusive Body, Doctors, Patients, and the Diagnosis Crisis, author and health journalist Alexandra Zifferlin offers a panoramic and personal analysis of this issue that affects so many of us.

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320.605 - 348.739 Erin Welsh

Her work takes her across the U.S., where she connects with patients, doctors, and researchers whose lives have been defined by the diagnosis crisis, like the family with a debilitating condition that went undiagnosed for years until they were able to find answers at the NIH's Undiagnosed Diseases Network, or the doctor whose cancer was dismissed by other physicians for years until she was finally able to get a diagnosis.

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348.719 - 373.532 Erin Welsh

As Sifferlin compassionately demonstrates, a diagnosis is more than a note on your medical chart. It can provide a path forward, treatment options, a supportive community, and the knowledge that you are believed. The elusive body is a highly relevant and much needed exploration of the diagnosis crisis in this country. And I am so excited to share my conversation with Alexandra with you all.

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373.993 - 376.937 Erin Welsh

So let's just take a quick break here and get into things.

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401.048 - 422.043 Erin Welsh

Alexandra, thank you so much for joining me today. Welcome to the show. Thank you so much for having me. Your book, The Elusive Body, it explores the many factors that prevent someone from receiving an accurate diagnosis, sometimes for decades. And before we dive into what some of those individual factors are, I'd love to hear about your journey in writing this book.

Chapter 6: How do cultural differences affect medical training and diagnostics?

422.303 - 425.368 Erin Welsh

How did you find yourself drawn to the diagnosis crisis?

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425.737 - 453.811 Alexandra Sifferlin

I got interested in diagnosis for both professional and personal reasons. I was a health journalist at Time Magazine, and I was discovering that one of the things that readers were emailing me about most often were issues related to their own unresolved diagnostic journey. So I would hear from people all the time basically asking me, you are interviewing a lot of physicians.

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454.171 - 473.698 Alexandra Sifferlin

Do you have any ideas of someone who could help me? I have been undiagnosed for this long. And it happened frequently enough that it felt like it was something worth looking into. I was just curious, what is it that causes someone to spend such a long period of time undiagnosed?

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473.678 - 496.243 Alexandra Sifferlin

And then personally, my book is dedicated to my sister, Francesca, who has experienced a variety of undiagnosed conditions over the years. And so I have been able to see firsthand how frustrating and destabilizing it can be to be suffering from something for which you have no solid answers.

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496.223 - 507.398 Alexandra Sifferlin

And so I just became very invested in both the scientific questions and also the personal anguish and how to resolve these things.

507.479 - 526.125 Erin Welsh

what results is this really thoughtful and broad ranging perspective on this massive problem that exists, not just in the United States, but around the world. And as you describe in your book, millions of people live without a diagnosis, sometimes for decades.

526.606 - 536.98 Erin Welsh

And the consequences of that can be extremely challenging, not just from a health standpoint, as their health deteriorates without any treatment or solution, but also emotionally and financially.

Chapter 7: What are the emotional impacts of living with undiagnosed conditions?

536.96 - 545.05 Erin Welsh

And starting with the basics, though, what is a diagnosis and how does receiving a correct diagnosis, what does that give someone?

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545.751 - 569.923 Alexandra Sifferlin

So at its most basic level, a diagnosis is basically an answer to what ails us. It's the identification of a disease or condition that explains the symptoms that a patient is experiencing. But a diagnosis goes so much more beyond that because a diagnosis is also really the beginning, ideally, of a resolution.

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569.983 - 596.31 Alexandra Sifferlin

So with a diagnosis, a physician can then build a treatment plan that will hopefully provide relief for their patient. A diagnosis is crucial for getting insurance coverage for said treatment plan or any follow-up appointments, etc., A diagnosis is important if, let's say, you have something rare and you want to be in an experimental clinical trial. You need a diagnosis for that.

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596.932 - 623.65 Alexandra Sifferlin

A diagnosis can also create access to a community if there's other people who are suffering from the same condition. And then I also think diagnosis can provide reassurance to people that they are experiencing something that is real. And it can provide a kind of coherence to their experience that sometimes has felt very unsettling or chaotic.

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623.63 - 646.58 Erin Welsh

And yet some people never receive that clear answer or kind of just linger in that liminal space of this like gray area for such a long time. And there are many different ways that this can happen in terms of like diagnostic error. Can you tell me about the different types of diagnostic error and how common they are just across the board in the United States?

646.62 - 651.387 Erin Welsh

Like how many people will receive a diagnostic error each year or within their lifetimes?

Chapter 8: What systemic changes are needed to improve diagnostic accuracy?

651.447 - 652.87 Erin Welsh

It's startling number.

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653.591 - 674.394 Alexandra Sifferlin

Yes, yes, definitely. So in 2015, the National Academies of Sciences, Engineering, and Medicine set out to do a really comprehensive report to sort of try to wrap their arms around diagnostic error and do their best attempt to estimate how how great an issue this was and try to understand it better.

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674.534 - 696.145 Alexandra Sifferlin

And basically, that report concluded that most people will experience a diagnostic error in their lifetime, sometimes with devastating consequences, whether that's disability or even death. Some conservative estimates suggest that 5% of American adults experience a diagnostic error every year. So that's something like

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696.125 - 722.217 Alexandra Sifferlin

10 to 13 million americans that is something that many people call a very conservative estimate so you're talking about tens of millions of people among that group of diagnostic error typically researchers look at diagnostic error in three buckets more or less there's a wrong diagnosis so the answer is incorrect you had heart failure but you were diagnosed with chronic bronchitis

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722.197 - 745.673 Alexandra Sifferlin

There's delayed diagnosis. So a diagnosis took longer than it should have. So perhaps a delayed diagnosis of cancer. And then there's missed diagnosis, which is someone is never diagnosed. They go on living undiagnosed. And so altogether, those are sort of the three buckets that we tend to look at when it comes to diagnostic error.

745.99 - 756.245 Erin Welsh

When it comes to delayed diagnosis, what is, is there like a bound around what is an acceptable time to diagnosis? You know, when, when does the diagnosis become delayed?

757.047 - 771.188 Alexandra Sifferlin

This one is a little bit complicated because medicine is inherently uncertain and no one expects that something very rare, like a very rare cancer would be diagnosed immediately. Right.

771.168 - 793.64 Alexandra Sifferlin

But what they sort of have determined is like, let's say a person comes in and you look back on their medical history and they were complaining about this cyst in their neck for years and years and years, and there was never any follow-up. And then you find out it's cancer and it's stage four. And that is sort of what would be determined as a delayed diagnosis.

793.94 - 818.033 Alexandra Sifferlin

It was something that generally medicine agrees could have been diagnosed earlier. Yeah. But, you know, it is complicated. Like, sometimes a person comes in complaining of symptoms, and there's nothing really coming up on tests yet. But as years go by, perhaps it does develop into something more serious. And so...

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