To Health With That! MTHFR Mutations and Methylation.
Episodes
Laura's MTHFR Story - Psoriasis, autoimmunity, and endometriosis.
22 Mar 2026
Contributed by Lukas
Laura bravely shares the story that has shaped her life in so many ways. Psoriasis, endometriosis, and multiple hospitalizations with a layer of MTHFR...
Monica's MTHFR Story - PCOS, Hives, and Histamine
08 Mar 2026
Contributed by Lukas
Monica was kind enough to share her health story with us, starting with a PCOS diagnosis, then thyroid antibodies, then uncontrollable hives, and fina...
Jesse's MTHFR Story - Mold Injury and Detoxification
22 Feb 2026
Contributed by Lukas
Jesse generously shares his story of MTHFR, chemical sensitivity, and mold injury. Mold illness can affect many people with MTHFR because of our slowe...
Christa's MTHFR Story - Amazing Son Helps Her Son Beat His Developmental Delay
18 Jan 2026
Contributed by Lukas
Christa generously shares the story of how discovering MTHFR and detoxifying completely changed the trajectory of her son's life, and their family...
Kelsey's MTHFR Story - Hormones, blood sugar and hemochromatosis.
21 Dec 2025
Contributed by Lukas
Today, Kelsey is kind enough to share her and her family's journey with MTHFR. Like the rest of us, their journey has unfolded slowly with a lot o...
Betsy's MTHFR Story - Rheumatoid Arthritis, methotrexate, and MTHFR
07 Dec 2025
Contributed by Lukas
Season 5, Episode 7 of the To Health With That! podcast. Betsy and I recorded this video several years ago (hence the hair!) and she was kind enough t...
Kristyn's MTHFR Story - Fatigue, Anxiety, Pericarditis
23 Nov 2025
Contributed by Lukas
Thank you so much to Kristyn for sharing her MTHFR story with us. Kristyn has only known she had an MTHFR gene variant for three months, but it makes ...
Tony's MTHFR Story Part 2 - Tumors, surgery, and anesthesia with MTHFR
09 Nov 2025
Contributed by Lukas
To Health With That! Podcast Season 5, Episode 5. Thank you so much to Tony for generously sharing his story - the full interview was fabulous and inc...
Tony's MTHFR Story - Part I. Anxiety, overwhelm, methyl folate intolerance
26 Oct 2025
Contributed by Lukas
To Health With That! Podcast Season 5, Episode 4. Thank you so much to Tony for generously sharing his story - the full interview was fabulous and inc...
Karene's MTHFR Story - ADHD, Sensitivity and Nutrient Deficiency
12 Oct 2025
Contributed by Lukas
Thank you so much to Karene for generously sharing her story! Karene is new to MTHFR - she just found out that she and her children have an MTHFR gene...
Mary's MTHFR story - MTHFR and repeat pregnancy loss.
28 Sep 2025
Contributed by Lukas
MTHFR Stories are interviews with regular people who have MTHFR and are willing to share their health journey to help others. Mary's MTHFR journey...
Lisa's MTHFR story - perfection, MTHFR, and self-acceptance
07 Sep 2025
Contributed by Lukas
Lisa's story is a testament to what having a community of people can do for your health journey. Lisa touches on many familiar MTHFR issues - alle...
What is Happening In Season Five? YOU'RE COMING ON THE PODCAST!
20 Jul 2025
Contributed by Lukas
The To Health With That! Podcast for MTHFR folks has been a wild ride, but so far it's really just Dr. Amy talking about MTHFR.In Season Five, whi...
Methylation Adaptogens, or Proof that God Loves Us.
01 Jun 2025
Contributed by Lukas
In the last episode, we talked about CBD as a methylation adaptogen, but we haven' talked too much about that term so let's dive in. We know t...
MTHFR and Marijuana. - What We Know Now.
27 Apr 2025
Contributed by Lukas
Pot is the third most used drug in North America after alcohol and tobacco, so questions about Cannabis and MTHFR are important to ask. The answers, o...
The Artist and The Activist Methylation Personality Types
16 Mar 2025
Contributed by Lukas
Methylation imbalance and the causative factors leading to methylation imbalance, like the MTHFR gene mutation, show themselves in four distinct perso...
The Achiever and The Athlete Personality Types
23 Feb 2025
Contributed by Lukas
,Methylation imbalance and the causative factors leading to methylation imbalance, like the MTHFR gene mutation, shows itself in four distinct persona...
Discover Your Methylation Personality: Achiever, Activist, Artist, Athlete.
12 Jan 2025
Contributed by Lukas
Methylation imbalance, often caused by the MTHFR gene mutation, by folic acid excess, or by nutritional deficiencies, shows itself in several personal...
Are Overmethylator and Undermethylator Still Useful Terms?
22 Dec 2024
Contributed by Lukas
I have used the terms over methylator and undermethylation in the past to help categorize people to streamline their supplement start with MTHFR or ot...
How Much Methyl Folate is Too Much for MTHFR?
17 Nov 2024
Contributed by Lukas
She breaks down the considerations for symptom management and potential risks, particularly regarding tumors and blood labs. In this episode of 'T...
The Risks of High Dose Folate
20 Oct 2024
Contributed by Lukas
Folate is a great thing - it's vitamin B9 and your body needs it to make new cells, replicate DNA, and so much more. But there are risks of too much f...
What's Happening With The THWT Podcast in September?
14 Jul 2024
Contributed by Lukas
That's right - season 4 of the To Health With That podcast is finished, so let's talk about what you should be doing this summer (having fun),...
Gentle Six Week Detox For MTHFR
30 Jun 2024
Contributed by Lukas
Gentle MTHFR Detox ProtocolA gentle six-week detoxification protocol tailored for individuals with MTHFR polymorphism. She explains how decreased meth...
Heal Your Adrenals - Part Two
16 Jun 2024
Contributed by Lukas
In Season 4, Episode 21 of the To Health With That podcast, naturopathic doctor Amy Neuzil discusses strategies to combat fatigue by focusing on adren...
Heal Your Adrenals - Part One
02 Jun 2024
Contributed by Lukas
In season four of the 'To Health With That' podcast, hosted by naturopathic doctor Amy Noozle, the focus shifts to understanding and combating...
Adrenal fatigue - What Stage Are You?
19 May 2024
Contributed by Lukas
In this episode of the 'To Health With That' podcast, host Amy Neuzil, a naturopathic doctor, explores adrenal fatigue, a widespread issue att...
Adrenals vs. The Modern World
05 May 2024
Contributed by Lukas
Understanding and Addressing Adrenal FatigueAdrenal fatigue is everywhere in modern culture, but why is that? It comes down to the difference between ...
Gene SNPs and Detox: What You Need To Know
21 Apr 2024
Contributed by Lukas
Doing a good detox protocol takes some preparation and some of the best preparation you can do is finding out if your genes are making detoxification ...
Why Does Detox Feel So Bad?
07 Apr 2024
Contributed by Lukas
Detox is amazing for your body, so why does it feel so awful? The great news is that symptoms of detoxification may be helpful in giving your signals ...
Detoxification Basics
24 Mar 2024
Contributed by Lukas
In the last episode, we discussed the fact that toxins come from food, air, water, personal care products, and pretty much everything we encounter. De...
Toxins: The Energy Killer
10 Mar 2024
Contributed by Lukas
Toxins are everywhere in modern life, and they have always been a normal part of life because they come from food, bacteria, mold, yeast, air, water, ...
You Don't Have Energy If You Don't Breathe
25 Feb 2024
Contributed by Lukas
Problems with oxygenation can affect your sleep quality and quantity, leaving you feeling tired, or like you slept but woke up as tired as you were th...
Hormones and Energy
11 Feb 2024
Contributed by Lukas
Sex hormones have a lot to do with how energetic you feel, or how sleepy, or how grumpy. So, let's talk about how estrogen ties into sleep, weight...
Supplements To Help You Sleep Through The Night
28 Jan 2024
Contributed by Lukas
There is nothing more frustrating than waking up in the middle of the night and not being able to go back to sleep easily. Nighttime waking is drainin...
Supplements To Help You Fall Asleep
14 Jan 2024
Contributed by Lukas
Supplements to help you fall asleep are a big topic, and there are many to choose from, but these are my favorite supplements to get you to sleep fast...
Master Your MTHFR Related Sleep Problems
31 Dec 2023
Contributed by Lukas
MTHFR gene mutations can create a lot of havoc in your life if they aren't properly managed and sleep disorders are just one of the many problems....
Sleep Anxiety
17 Dec 2023
Contributed by Lukas
Sleep anxiety is the horror circle that lies at the intersection of insomnia and anxiety disorders that createes a torturous loop in which a person is...
Can't Fall OR Stay Asleep, and Sleep but Wake Feeling Unrested
03 Dec 2023
Contributed by Lukas
There are four big categories of sleep disorders and today we'll talk about the last two. Numbers one and two were in the last episode, so if you ...
Can't Fall Asleep and Can't Stay Asleep - But Why?
19 Nov 2023
Contributed by Lukas
There are four big categories of sleep disorders and today we'll talk about the first two. Number one is hard time falling asleep and number two is ha...
Sleep Basics and 8 Keys To A Healthy Sleep-Wake Cycle
05 Nov 2023
Contributed by Lukas
Sleep is one of our basic bodily functions and a key to good daytime energy and productivity. We'll talk about what sleep is, what it's for, a...
What Makes You Feel Energetic?
22 Oct 2023
Contributed by Lukas
While we're talking about fatigue, it's important to also talk about what helps you feel energetic, because sometimes knowing what gives you e...
Why Do Depression and Fatigue Look the Same?
08 Oct 2023
Contributed by Lukas
Depression and fatigue look incredibly similar, but we treat them totally differently. Maybe it's time for treatment strategies to begin to overla...
Fatigue First Step - Rule Out The Basics
24 Sep 2023
Contributed by Lukas
The first step to tackling your fatigue and getting your energy back, is finding out if there is something underneath, causing the fatigue, that you c...
What is Fatigue And Why Are We All Exhausted?
10 Sep 2023
Contributed by Lukas
Fatigue and exhaustion are going around - we are all struggling. But why? What is really going on here? What is fatigue, what causes it, and why does ...
Drumroll please... Season 4 Topic Announcement.
14 May 2023
Contributed by Lukas
I have enjoyed this season so much - the interweaving of MTHFR and fertility and the ever-interesting conversation about women's health and hormon...
Fad Diets and Disordered Eating for Fertility
30 Apr 2023
Contributed by Lukas
There is a new fad diet every 20 minutes, or at least it feels that way. It could be paleo, ancestral, keto, the potato diet, the grapefruit diet, the...
The BEST Diet for Fertility
23 Apr 2023
Contributed by Lukas
The best diet for fertility sounds like a big claim to make, but the science is clear about what is needed and what isn't. This episode we'll ...
Ideal Medicine vs. Medicine In Real Life
02 Apr 2023
Contributed by Lukas
Of course there is a perfect way to do things if you have all the money, time, and resources to throw at it, but what about what actually happens in r...
Oocyte aging, or Old Eggs in Fertility
26 Mar 2023
Contributed by Lukas
This week we're talking about "advanced maternal age" which is the medical term for women having babies over the age of 35. The real pro...
Iron Levels and Infertility
19 Mar 2023
Contributed by Lukas
Iron deficiency anemia can be a significant problem when you're trying to conceive or going into a pregnancy, but even without overt iron deficiency a...
Subclinical hypothyroid and Fertility
12 Mar 2023
Contributed by Lukas
Overtly low or overtly high thyroid levels are a well known risk factor for infertility, but today we're going to talk about something a little bit le...
MTHFR, Fertility, and Pregnancy - Everything You Need to Know
05 Mar 2023
Contributed by Lukas
MTHFR is involved in so many processes, but it is especially tangled up with fertility for both male and female partners, as well as pregnancy for fem...
Mental Health and Infertility
26 Feb 2023
Contributed by Lukas
The infertility journey can be a difficult path and is often an endurance race with sprints mixed in. This episode is less about mental health e...
PCOS and Infertility
12 Feb 2023
Contributed by Lukas
PCOS is one of the more common causes of female-factor infertility because it creates a situation in which ovulation is unpredictable or not occurring...
Endometriosis Deep Dive
05 Feb 2023
Contributed by Lukas
Last week we talked about how endometriosis affects fertility and pregnancy outcomes. This week, let's dive deeper into what is really going on with e...
Endometriosis and Fertility Deep Dive
29 Jan 2023
Contributed by Lukas
Endometriosis is one of the leading causes of female factor infertility and it's responsible for incredibly painful menses, heavy bleeding, and often ...
What To Expect From Your ND for Fertility
22 Jan 2023
Contributed by Lukas
Lots of people come to NDs to help them on their fertility journey, but what does an ND actually do? In short, your ND can support your fertility jour...
The Complete Infertility Evaluation, Explained
15 Jan 2023
Contributed by Lukas
The idea of getting an infertility evaluation is a daunting one, but it gives you such a wealth of valuable information and can help you to steer your...
Charting Your Cycle For Fertility
08 Jan 2023
Contributed by Lukas
This week we're talking about a basic tool in every woman's arsenal, it's tracking her period and charting her cycle. Especially on the fertility jour...
Folic Acid vs. 5-LMTHF in Pregnancy and Fertility
01 Jan 2023
Contributed by Lukas
Folic acid is the standard of care for both prenatal vitamins and high doses for couples struggling with infertility. So let's look at a compelling re...
Seed Cycling for Hormone Balance - Can It Be So Simple?
18 Dec 2022
Contributed by Lukas
Seed Cycling sounds too simple to work, but it's a lovely nutritive way to get your menstrual cycle back in balance. This technique uses a combination...
Red Flags for Women's Hormone Abnormalities That Affect Fertility - Part 2
11 Dec 2022
Contributed by Lukas
There are so many women's hormone symptoms that women have regularly that we think of as a "normal" part of being a woman, but that might give you som...
Red Flags for Women's Hormone Abnormalities in Infertility - Part 1
04 Dec 2022
Contributed by Lukas
There are lots of red flags in every day life that might indicate a hormone imbalance or other problem that could have fertility consequences. This we...
Hidden Fertility Information in Your Annual Exam
27 Nov 2022
Contributed by Lukas
Your annual exam isn't normally the place where you're looking for fertility insights, but if you know where to look there is hidden information in: ...
Preconception Supplements for Gene SNPs
20 Nov 2022
Contributed by Lukas
Last week we talked about basic preconception supplements. This week, we expand on that and add some specifics about: Magnesium Choline Iron and ...
Preconception Supplements - Part 1.
13 Nov 2022
Contributed by Lukas
Lots of people talk about what you need to take while you're pregnant, but what about the supplements that will boost your fertility and give your bab...
Fix These Things Before Trying To Get Pregnant
06 Nov 2022
Contributed by Lukas
If you're in the ideal situation of planning things out before you decide to get pregnant, then here are the factors you should work on before you try...
Preconception Care - What Do You Really Need?
30 Oct 2022
Contributed by Lukas
Lots of us have babies without a lot of planning, but if you have the opportunity to plan your family then here is information about: Questions to a...
Progesterone, Testosterone, Pituitary Hormones, and What is in Basic Fertility Work-Up
24 Oct 2022
Contributed by Lukas
Last week, we talked about Estrogen, the primary female sex hormone. This week, let's round out the conversation with a discussion about progesterone,...
Estrogen. What Fresh Hell is This?
16 Oct 2022
Contributed by Lukas
We've all heard of estrogen, of course, but how much do you really know about it? Let's talk about why estradiol is called the Marilyn Monroe hormone....
What About The Men? Spermatogenesis.
09 Oct 2022
Contributed by Lukas
We already talked about what happens in women's bodies, but what about men? How do men make sperm that will be healthy enough to win the egg race? Let...
Four Phases of A "Normal" Menstrual Cycle
02 Oct 2022
Contributed by Lukas
To begin to talk about what is abnormal about women's menstrual cycles, we have to first understand what is normal. Most doctors and experts ten...
Why Diagnosis Matters For Fertility
25 Sep 2022
Contributed by Lukas
It's really tempting to avoid the diagnosis part of fertility - you can just get a bit healthier and it will all work out, right? Except for when it w...
Are you "Infertile" without even knowing it?
18 Sep 2022
Contributed by Lukas
For the first episode of this season on infertility, hormones, and how it all ties in with genetics - let's actually talk about what "infertility" mea...
S2E45: MTHFR and Vaccines
24 Jul 2022
Contributed by Lukas
The internet is full of doomsday prophecies about MTHFR and vaccines, but what does the actual science say? In this episode we'll cover:Dr. Amy...
S2E44: Natural skincare for chemically sensitive MTHFR folks with Renee Harris
17 Jul 2022
Contributed by Lukas
Living the MTHFR lifestyle means reducing as much toxic exposure as possible and a lot of that comes through skincare. Today, Dr. Amy is talking with ...
S2E42: Emotional Eating - an Interview with Tricia Nelson
10 Jul 2022
Contributed by Lukas
Tricia Nelson is an emotional eating expert and the author of Heal Your Hunger: 7 Simple Steps to End Emotional Eating. I am delighted to have t...
S2E42: PEMT, Every Cell In Your Body, and MTHFR
03 Jul 2022
Contributed by Lukas
If I had to pick one mutation that was AS pivotal as MTHFR is, it would be PEMT. This mutation affects literally EVERY cell in your body - all 37.2 tr...
S2E41: MAO-A Fast and the Carbohydrate Rollercoaster
26 Jun 2022
Contributed by Lukas
This week we'll talk about another gene SNP picture that is called MAO-A Fast. Having a fast MAO-A means you break down neurotransmitters faster than ...
S2E40: MAO-A Slow And The Short Fuse
19 Jun 2022
Contributed by Lukas
MAO-A is another gene SNP that is different from the others we've talked about because it is actually linked to a sex chromosome. The various SNPs add...
S2E39: Vitamin D, VDR, and MTHFR.
12 Jun 2022
Contributed by Lukas
Vitamin D doesn't link into the methylation cycle, the folate cycle, or even the BH4 pathway so it seems highly unrelated to MTHFR, but is that true? ...
S2E38: Is Low Histamine Actually a Problem?
05 Jun 2022
Contributed by Lukas
Low histamine isn't something that doctors are talking about yet. It hasn't even really made it to the internet, which is usually first to know everyt...
S2E37: High Histamine, MTHFR, and other Gene SNPs.
29 May 2022
Contributed by Lukas
Histamine and MTHFR are joined together in so many ways. Let's talk about: The surprising things other than allergies that histamine influences. Ri...
Arsenic, Mercury, and Fibromyalgia. Questions from Listeners.
15 May 2022
Contributed by Lukas
I love listener questions because it's always something good! This week, we talk about: Detoxifying Arsenic Mercury toxicity with adrenal fatigue a...
S2E35: Nitric Oxide, MTHFR, and the NOS3 gene SNP.
08 May 2022
Contributed by Lukas
MTHFR is closely tied to heart disease, and nitric oxide (not to be confused with nitrous oxide, or laughing gas) is a big part of the reason why. In ...
S2E34: B12, MTR, and MTRR
01 May 2022
Contributed by Lukas
Of course B12 is important to methylation and MTHFR, but why is that precisely? Well, spoiler alert - it has something to do with two different genes ...
S2E33: GST and GPX - Two Gene SNPs That Mess With Glutathione
24 Apr 2022
Contributed by Lukas
We've talked about glutathione before, but now let's talk about two gene SNPs that really mess with your glutathione functioning. We'll discuss: Sig...
S2E32: Glutathione Basics
17 Apr 2022
Contributed by Lukas
We've talked about glutathione before, but let's review before we dive into gene SNPs that affect glutathione. We'll cover: The most common fatal ov...
S2E31: COMT Fast
10 Apr 2022
Contributed by Lukas
With a COMT Fast picture we see an overly-efficient enzyme that gets rid of crucial substances before they have the chance to act. We'll talk about: ...
S2E30: COMT Slow
03 Apr 2022
Contributed by Lukas
The COMT slow picture affects neurotransmitters, stress hormones, and estrogen. This week we'll talk about: Signs and symptoms of a slow COMT. How ...
COMT and MTHFR
27 Mar 2022
Contributed by Lukas
To kick off our series about other genetic polymorphisms, we're starting with a heavy hitter called COMT. This week we'll talk about: What COMT mean...
S2E28: Other Gene SNPs with MTHFR
20 Mar 2022
Contributed by Lukas
MTHFR is not the only gene SNP out there - I know, you'd never know that if you listen to this podcast. So let's start a mini-series about other polym...
S2E27: What Is Really Going On With MTHFR Basic State?
13 Mar 2022
Contributed by Lukas
MTHFR Basic States are an idea that generates a lot of controversy. Some well-respected practitioners don't like to use the idea at all, and some do. ...
S2E26: Supplements for Depression with MTHFR
27 Feb 2022
Contributed by Lukas
We've talked about so many facets of depression with MTHFR - including the link between MTHFR and neurotransmitter formation, overlooked causes of dep...
S2E25: MTHFR Questions From Listeners - Products and Marmite.
20 Feb 2022
Contributed by Lukas
Listeners Liana and Tim asked a couple of great questions this week so let's dive into them. Liana asks about specific product suggestions for 5-LMTHF...
S2E24: Checking In with Your Progress With MTHFR
14 Feb 2022
Contributed by Lukas
We haven't touched base about what is happening for you right now with MTHFR, so today is the day. Let's talk: Why we don't need to be changing thin...
S2E23: The Risks of UMFA in Pregnancy
06 Feb 2022
Contributed by Lukas
Last week we talked about the remarkable results 5-LMTHF produced in couples struggling with infertility relative to high-dose folic acid, which is th...
S2E22: The Harm that 5000 mcg Folic Acid Can Do To Fertility with MTHFR
30 Jan 2022
Contributed by Lukas
5000 mcg folic acid is the standard of care for pregnancies that are considered high-risk and pregnancies in couples struggling with infertility. Unfo...
Supplements for Anxiety with or without MTHFR
23 Jan 2022
Contributed by Lukas
I'm hoping it goes without saying that balancing your methylation is the first step you should consider taking with anxiety, with or without a known M...
S2E20: MTHFR and Anxiety - An Interview with Jennifer Bronsnick
16 Jan 2022
Contributed by Lukas
MTHFR and Anxiety can go hand in hand, so let's hear from anxiety expert Jennifer Bronsnick about her own anxiety journey and some of the tools she ha...