Opioid toxicity remains one of the most important toxicologic emergencies encountered in emergency medicine, critical care, EMS, and hospital medicine. In this episode, we break down opioid overdose from the ground up including opioid pharmacology, respiratory depression physiology, recognition of the opioid toxidrome, naloxone administration, airway management, ventilator considerations, post-reversal monitoring, and ICU management strategies. We also discuss: • Hypoventilation and hypercapnia • End tidal CO2 monitoring • Pulmonary edema in opioid overdose • Long-acting opioids and recurrent toxicity • Co-ingestions and diagnostic pitfalls • Intubation considerations in critically ill overdose patients This episode is designed for medical students, residents, fellows, nurses, respiratory therapists, advanced practice providers, and practicing clinicians looking for a high-yield review of opioid toxicity and overdose management. Watch the full YouTube video here: https://www.youtube.com/watch?v=aUjvkQq4kJg 🔗 Download the full study guide + access our complete emergency critical care curriculum: https://www.patreon.com/c/WhiteBoardMedicine Our Patreon includes: • Study guides for every video • Mini-courses (ventilation, shock, RRT & more) • Practice questions • Ad-free videos • A structured ICU curriculum WhiteBoard Medicine Podcast: https://podcasts.apple.com/us/podcast/whiteboard-medicine-emergency-and-critical-care/id1808306430 Disclaimer: WhiteBoard Medicine content is intended for educational purposes only and should not be interpreted as medical advice, diagnosis, or treatment recommendations. Clinical decisions should always be made using independent medical judgment, current guidelines, institutional protocols, and specialist consultation when appropriate.

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“What did the council decide on item 42?” — answered with the speaker and the moment.

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