Salicylate toxicity is one of the most important acid-base and toxicologic emergencies encountered in emergency medicine, critical care, and hospital medicine. In this episode, we break down salicylate poisoning from the ground up including salicylate pharmacology, acid-base physiology, respiratory alkalosis, metabolic acidosis, sodium bicarbonate therapy, hemodialysis indications, airway management, and ICU management strategies. We also discuss: • Recognition of salicylate toxicity • Tachypnea and compensatory hyperventilation • Salicylate distribution and tissue penetration • Pulmonary edema and CNS toxicity • Volume depletion and electrolyte abnormalities • Intubation pitfalls in salicylate poisoning • Why mechanical ventilation can rapidly worsen critically ill patients • Co-ingestions and diagnostic challenges This episode is designed for medical students, residents, fellows, nurses, respiratory therapists, advanced practice providers, and practicing clinicians looking for a high-yield review of salicylate toxicity and acid-base disorders in critical illness. Watch the full YouTube video here: https://www.youtube.com/watch?v=tcUS6v_Cktc 🔗 Download the full study guide + access our complete emergency critical care curriculum: https://www.patreon.com/c/WhiteBoardMedicine Our Patreon includes: • Study guides for every video • Mini-courses (ventilation, shock, RRT & more) • Practice questions • Ad-free videos • A structured ICU curriculum WhiteBoard Medicine Podcast: https://podcasts.apple.com/us/podcast/whiteboard-medicine-emergency-and-critical-care/id1808306430 Disclaimer: WhiteBoard Medicine content is intended for educational purposes only and should not be interpreted as medical advice, diagnosis, or treatment recommendations. Clinical decisions should always be made using independent medical judgment, current guidelines, institutional protocols, and specialist consultation when appropriate.

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