Toxicologic emergencies are common in emergency medicine and critical care, yet the underlying physiology and management strategies can become complex quickly. Early recognition and aggressive supportive care are often critical to improving outcomes. In this ICU toxicology masterclass, we review four high-yield toxicologic emergencies every clinician should recognize: • Beta blocker toxicity • Calcium channel blocker (CCB) toxicity • Salicylate toxicity • Acetaminophen toxicity Topics discussed include: • Bradycardia and shock physiology • Vasodilatory vs cardiogenic shock • Hyperinsulinemic euglycemia therapy • Glucagon • Calcium therapy • Vasopressors • Salicylate acid-base abnormalities • Respiratory alkalosis and metabolic acidosis • Tinnitus and altered mental status • Acetaminophen metabolism and NAPQI toxicity • N-acetylcysteine (NAC) • ICU and emergency department management pearls This episode is designed for physicians, nurses, pharmacists, respiratory therapists, trainees, and anyone interested in emergency critical care medicine and toxicology. 🎥 YouTube video: https://www.youtube.com/watch?v=9881EJ-PZK0 ☠️ Toxicology Playlist: https://www.youtube.com/playlist?list=PLf5bMa9_tvRhJ5KnBNdycGFO6k1d_smJX 📚 Download the study guide + access our complete emergency critical care curriculum: https://www.patreon.com/c/WhiteBoardMedicine Our Patreon includes: • PDF study guides for every episode • Emergency critical care mini-courses • Practice questions • Ad-free content • A structured ICU curriculum 🎧 WhiteBoard Medicine Podcast: https://podcasts.apple.com/us/podcast/whiteboard-medicine-emergency-and-critical-care/id1808306430 DISCLAIMER: This content is intended for educational purposes only and should not be considered medical advice. Clinical decisions should always be made using independent medical judgment, current guidelines, institutional protocols, and consultation with appropriate specialists. This content does not establish a physician-patient relationship and may not reflect the views of any affiliated institutions or employers.

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