Hepatopulmonary syndrome is an important pulmonary vascular complication of liver disease and portal hypertension. In this episode, we review the pathophysiology, clinical presentation, diagnostic evaluation, and treatment of hepatopulmonary syndrome. Topics covered include: • What hepatopulmonary syndrome is • The relationship between liver disease, portal hypertension, and hypoxemia • Intrapulmonary vascular dilatations • Ventilation-perfusion mismatch and impaired oxygenation • Clinical presentation and symptoms • Platypnea and orthodeoxia • Diagnostic evaluation • Pulse oximetry and arterial blood gas testing • Contrast-enhanced echocardiography • Differentiating hepatopulmonary syndrome from portopulmonary hypertension • Treatment options and supportive care • Role of liver transplantation Watch the full video on YouTube: https://www.youtube.com/watch?v=rUEJSEDFbrY 📚 Support WhiteBoard Medicine on Patreon https://www.patreon.com/WhiteBoardMedicine Take your learning beyond the podcast with access to: • Comprehensive Study Guides • Bedside One-Pagers • Clinical Reviews • Mini-Courses • Practice Questions • Ad-Free Videos • Structured Topic Collections Your support helps us continue creating high-yield WhiteBoard Medicine content for YouTube, podcasts, and beyond. ⚠️ Educational Disclaimer: This content is intended for educational purposes only and should not be used as a substitute for clinical judgment, institutional protocols, specialist consultation, or individualized patient care. Full disclaimer: https://whiteboardmedicine.com/disclaimer

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