In this episode, we rewind to one of biology’s biggest plot twists: RNA interference (RNAi). Scientists found that injecting double-stranded RNA into Caenorhabditis elegans could silence genes powerfully and precisely—far beyond anything single strands could achieve.This game-changing discovery revealed:How dsRNA triggers targeted gene shutdownWhy only a few molecules can silence thousands of cellsHow gene silencing spreads across tissuesThe first clues toward RNA-based therapies that would change medicine forever📖 Based on the research article:“Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans”Andrew Fire, SiQun Xu, Mary K. Montgomery, Steven A. Kostas, Samuel E. Driver & Craig C. Mello.Published in Nature (1998).🔗 https://doi.org/10.1038/35888🎧 Subscribe to the WoRM Podcast for more whole-organism stories that changed the world!🔗 www.veerenchauhan.com

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