Amit Etkin

speaker
111 appearances 2 recordings 1 series first heard Jul 2005 last heard Mar 2015

Amit Etkin’s voice in public audio — every appearance, attributed to the second.

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Anytime that something happens that's surprising, that's good or bad, something that requires your attention, that you need to focus on or away, this region, these set of regions activate and they work together.
So it really is an anatomically interconnected circuit whose function is coherent.
Exactly.
And the loss was such that when you lose brain tissue in one region, you'll lose brain tissue in the other regions.
In other words, it really is a circuit that's lost.
That's right.
The degree of loss differed by disorder in roughly the way you would think if you looked at severity of the disorder in terms of its impact on life.
So the more profound the disorder, the more the loss.
Exactly.
There actually could be many things, all of which give interesting answers and raise some very interesting questions.
So you could ask, for example, is this a chicken or egg?
Is this something that happens to put you at risk for the disorder?
Any disorder?
Or is it something that happens that's progressive?
And it actually seemed like the answer is both a chicken and an egg.
For example, things like childhood maltreatment, which put you at risk for a range of disorders, affect activity in these regions.
Progression of disorders like schizophrenia decrease gray matter in these regions.
So you see both chicken and egg.
And so the question that really comes out of this ultimately is, is this a common bottleneck that you go through whatever the cause of the disorder that leads to impairments in higher level cognitive capacities and in your functioning in life?
Or does it really matter how you got there?
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