Andrew Steele
👤 PersonAppearances Over Time
Podcast Appearances
They live a bit longer, which is a good thing, but they're not just sort of stumbling along in ill health, unable to muster the energy even to die. They're healthier, they get less cancer, they get less heart disease, they get fewer cataracts. They're less frail, so they can run further and faster on the little mousy treadmills that they use in these experiments. They're more curious.
They live a bit longer, which is a good thing, but they're not just sort of stumbling along in ill health, unable to muster the energy even to die. They're healthier, they get less cancer, they get less heart disease, they get fewer cataracts. They're less frail, so they can run further and faster on the little mousy treadmills that they use in these experiments. They're more curious.
They live a bit longer, which is a good thing, but they're not just sort of stumbling along in ill health, unable to muster the energy even to die. They're healthier, they get less cancer, they get less heart disease, they get fewer cataracts. They're less frail, so they can run further and faster on the little mousy treadmills that they use in these experiments. They're more curious.
So if you put a young mouse in a maze, it's often very exploratory. It wants to look around its new environment. An older mouse might be a bit more anxious, maybe just a bit lazier, because it's a bit more frail. And by giving mice these senolytic drugs that kill the senescent cells, you restore some of that youthful curiosity. And finally, these animals, they just look great.
So if you put a young mouse in a maze, it's often very exploratory. It wants to look around its new environment. An older mouse might be a bit more anxious, maybe just a bit lazier, because it's a bit more frail. And by giving mice these senolytic drugs that kill the senescent cells, you restore some of that youthful curiosity. And finally, these animals, they just look great.
So if you put a young mouse in a maze, it's often very exploratory. It wants to look around its new environment. An older mouse might be a bit more anxious, maybe just a bit lazier, because it's a bit more frail. And by giving mice these senolytic drugs that kill the senescent cells, you restore some of that youthful curiosity. And finally, these animals, they just look great.
You know, I was a computational biologist, so I never dealt with mice in the lab. And if you look at a picture of one of these mice that's had these drugs, they've got better fur, they've got thicker, plumper skin. They just look fantastic. And so the point is, you know, you can't diet and exercise and live a good life to a healthy, you know, guaranteed healthy hundred years old.
You know, I was a computational biologist, so I never dealt with mice in the lab. And if you look at a picture of one of these mice that's had these drugs, they've got better fur, they've got thicker, plumper skin. They just look fantastic. And so the point is, you know, you can't diet and exercise and live a good life to a healthy, you know, guaranteed healthy hundred years old.
You know, I was a computational biologist, so I never dealt with mice in the lab. And if you look at a picture of one of these mice that's had these drugs, they've got better fur, they've got thicker, plumper skin. They just look fantastic. And so the point is, you know, you can't diet and exercise and live a good life to a healthy, you know, guaranteed healthy hundred years old.
Whereas by using some of these drugs that could potentially slow down, maybe even reverse the aging process, we can allow ourselves to live longer and healthier than any current lifestyle intervention would allow.
Whereas by using some of these drugs that could potentially slow down, maybe even reverse the aging process, we can allow ourselves to live longer and healthier than any current lifestyle intervention would allow.
Whereas by using some of these drugs that could potentially slow down, maybe even reverse the aging process, we can allow ourselves to live longer and healthier than any current lifestyle intervention would allow.
Well, we're going to have to wait for some of the clinical trials to happen. So I'm very excited that these things are going to be here in time for all of us because they're already in human clinical trials. But at the moment, you know, mostly we're looking at results in mice and we've got the first tentative results starting to come out in humans.
Well, we're going to have to wait for some of the clinical trials to happen. So I'm very excited that these things are going to be here in time for all of us because they're already in human clinical trials. But at the moment, you know, mostly we're looking at results in mice and we've got the first tentative results starting to come out in humans.
Well, we're going to have to wait for some of the clinical trials to happen. So I'm very excited that these things are going to be here in time for all of us because they're already in human clinical trials. But at the moment, you know, mostly we're looking at results in mice and we've got the first tentative results starting to come out in humans.
So hopefully in the next five or so years, we're going to have some of those answers. Do these drugs work in humans as well as they do in mice? And we can start thinking about taking them.
So hopefully in the next five or so years, we're going to have some of those answers. Do these drugs work in humans as well as they do in mice? And we can start thinking about taking them.
So hopefully in the next five or so years, we're going to have some of those answers. Do these drugs work in humans as well as they do in mice? And we can start thinking about taking them.
It actually is, yeah. There's a fascinating study that was done a few years ago where people were asked to rate the photographs of other people to guess how old they thought they were. And what they found was that people who looked older tended to have a greater risk of dying in the near future and a greater risk of contracting certain diseases.
It actually is, yeah. There's a fascinating study that was done a few years ago where people were asked to rate the photographs of other people to guess how old they thought they were. And what they found was that people who looked older tended to have a greater risk of dying in the near future and a greater risk of contracting certain diseases.