Brandon (Host)
speaker
390 appearances
3 recordings
1 series
first heard Jun 2026
last heard 16 Jul
Brandon (Host)’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 3 in all, peaking in Jul 2026 with 2.
Appearances
unlike an image which is blurry, you don't even know it's blurry.
You flip around an aromatic ring and it looks just fine.
So maybe it's almost like with a lot of generative image models, they will fill in a detail which just doesn't exist.
So if you were to try to do like forensics and you tell your vision transformer to enhance an image and suddenly it just pops up a face, but that's actually not the person's face.
Right.
But like, you don't know that and it feels just fine.
And so if you're trying to use this as a structural hypothesis, as a med chemist, you're kind of screwed.
If you're looking at the wrong face as an investigator, it's not going to take.
Yeah.
We talked about poses.
So maybe the contrarian take is that a pose isn't even a well-defined concept and that, you know, the best way of thinking about these things is just like...
you know, probability distribution over things.
And there's a small molecule which probably lives in a binding pocket, something like this.
I mean, is this pose... Like, this is an abstraction that humans use and not really, in some sense, ground truth.
So I'm actually almost...
I'm kind of interested to actually hear that like, oh, we have this one instrument threshold.
This is like really important for med chemists.
I would also talk to some chemists who would say, I mean, this pose isn't even real.
This is just like maybe a most probable configuration or, you know, how do you think about that abstraction in general?
And do you explore conformational space and provide that as tools?
Showing 201–220 of 390 · page 11 of 20
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