Bruce Miller
speaker
109 appearances
1 recordings
1 series
first heard Mar 2022
last heard Mar 2022
Bruce Miller’s voice in public audio — every appearance, attributed to the second.
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Appearances
It was the last thing that we did.
For me, the hardest and maybe most interesting chapter that I had to write was
We decided that we should write about behavior because this is an area I think a lot about and it's an area that is so devastating for patients and families.
It was very much a back and forth.
I think mostly we really liked what each other wrote and there wasn't a lot of editing or change.
At least that's my memory.
Yeah, so there's a little clip of the chapter on diagnosis.
It's called Where Dementia Decides to Dance.
It's about where the disease begins in the brain.
I think the more we think about that, the more we learn about who that person was before the illness started.
So we've learned that almost 50% of the people
who get Alzheimer's disease where language is the first manifestation were dyslexic or didn't read.
This early life pattern explains to some extent the loss of function later in life.
It's profoundly interesting and I think it has potential for new therapies as well.
So a lot of my work has focused on the frontotemporal dementias, and they hit the frontal lobe and the anterior temporal lobe.
And if it begins on the left side, if it begins in the frontal lobe, it begins with
difficulty generating speech, and so the speech becomes much less likely to occur, people become quieter, there are shorter sentences, and eventually, even at a time when someone is fully functional, they may be mute.
That we have since, as we've described it, Marilu Gorno-Tempini was the one who did this.
We've learned that almost all those cases are caused not by Alzheimer's, but a type of frontotemporal dementia where tau protein is responsible.
For me as a neurologist, this is so amazing.
Showing 41–60 of 109 · page 3 of 6
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