Charles Piller

It shows the apparent flaws in the images. it requests that the scientists behind the work take a close look at it. And often, it gives fodder for an examination by the journals that published the work. So this is one way in which I feel optimistic. It's forcing a greater concern about making science the most powerful, the most reliable it can be. And that's the forensic image sleuths.

It shows the apparent flaws in the images. it requests that the scientists behind the work take a close look at it. And often, it gives fodder for an examination by the journals that published the work. So this is one way in which I feel optimistic. It's forcing a greater concern about making science the most powerful, the most reliable it can be. And that's the forensic image sleuths.

The other thing is I think that as much as the amyloid hypothesis of Alzheimer's has been dominant for many, many years, has received the most attention, Yet in recent years, there have been a few other ideas that I think are potentially fruitful and interesting that I have my eye on. And I would certainly encourage people who are interested to think about and examine.

The other thing is I think that as much as the amyloid hypothesis of Alzheimer's has been dominant for many, many years, has received the most attention, Yet in recent years, there have been a few other ideas that I think are potentially fruitful and interesting that I have my eye on. And I would certainly encourage people who are interested to think about and examine.

And I can give a couple of examples of those. One is right now, the kind of the GLP-1 inhibitors. These are the drugs like Wegovy and others that have hit the world by storm of late. And whatever pros and cons there are of these things, they have become very important drugs in our world.

And I can give a couple of examples of those. One is right now, the kind of the GLP-1 inhibitors. These are the drugs like Wegovy and others that have hit the world by storm of late. And whatever pros and cons there are of these things, they have become very important drugs in our world.

But one of the interesting things about it is that scientists have found that it's possible that they may have beneficial effects on early stage dementia. And as a result, they're being tested in people. I think within

But one of the interesting things about it is that scientists have found that it's possible that they may have beneficial effects on early stage dementia. And as a result, they're being tested in people. I think within

probably by sometime early in 2026, just no more than about a year from now, we may know whether those hopes, the early evidence that we've seen with those drugs might prove to be true and correct. And it might be an avenue that some patients might be able to travel to have a better, more hopeful experience with the progression of their disease.

probably by sometime early in 2026, just no more than about a year from now, we may know whether those hopes, the early evidence that we've seen with those drugs might prove to be true and correct. And it might be an avenue that some patients might be able to travel to have a better, more hopeful experience with the progression of their disease.

The other thing that I think people often forget about is that certain infections that seem like they're gone, like one example is herpes virus that people might get that causes cold sores, but then goes away. And people think, okay, I'm done with that.

The other thing that I think people often forget about is that certain infections that seem like they're gone, like one example is herpes virus that people might get that causes cold sores, but then goes away. And people think, okay, I'm done with that.

But it can somehow, sometimes I should say, be a latent infection that hangs out in internal organs, including the brain, for many years, even decades, after the person has apparently gotten over the disease and gotten over the infection. And people are studying the effects of these latent infections on dementia. And it's possible that it could be a factor in Alzheimer's disease.

But it can somehow, sometimes I should say, be a latent infection that hangs out in internal organs, including the brain, for many years, even decades, after the person has apparently gotten over the disease and gotten over the infection. And people are studying the effects of these latent infections on dementia. And it's possible that it could be a factor in Alzheimer's disease.

And there's trials going on right now, again, that I think within a few years might have fruitful information that could prove beneficial in understanding the possibility that there's other avenues involved.

And there's trials going on right now, again, that I think within a few years might have fruitful information that could prove beneficial in understanding the possibility that there's other avenues involved.

maybe in concert with the amyloid hypothesis or maybe separate from it, that could have a lot of impact in helping, if not cure people, at least helping the cognitive symptoms become less bad or be arrested in some way. Now, there's one other thing I wanted to mention, Dylan, and I know this is most certainly an interest of yours, which is prevention.

maybe in concert with the amyloid hypothesis or maybe separate from it, that could have a lot of impact in helping, if not cure people, at least helping the cognitive symptoms become less bad or be arrested in some way. Now, there's one other thing I wanted to mention, Dylan, and I know this is most certainly an interest of yours, which is prevention.

And one of the things that I feel hopeful about is that it's becoming more known nationally and globally that We do have agency in our lives, even when it comes to a dreaded disease like Alzheimer's that sometimes seems so mysterious. We know very well that there are certain things that are risk factors for the disease, things like high blood pressure, high cholesterol,

And one of the things that I feel hopeful about is that it's becoming more known nationally and globally that We do have agency in our lives, even when it comes to a dreaded disease like Alzheimer's that sometimes seems so mysterious. We know very well that there are certain things that are risk factors for the disease, things like high blood pressure, high cholesterol,