Chris Masterjohn

We'll put them on the next one.

They just rotate through it.

Because they're just looking at it like they have a model that predicts their hypothesis that they'll respond.

They didn't.

So they switched them on to the next approach.

So because medicine cares about triaging decisions about what to do for treatment, they say, I only need a model that helps me do that and I can ignore all the other details.

But what happens is you leave these historical threads behind, like the fact that the –

chair of the conference that proved to put in your magazine that everyone had to change their diet because of the concept that they said was proven that is now the basis for the drugs that I'm going to prescribe you.

The fact that he had these, you know, that he also showed that it was seed oils in the membrane of the LDL particle that drive the plaque doesn't matter because that doesn't change whether I'm going to give you a statin, you know?

And so,

And so if it doesn't change how I'm going to treat you, it doesn't matter, which means that I could ignore it if someone asked me what you should eat.

But the problem was when they did the randomized controlled trials with the seed oils, they were like, oh, it doubled the atherosclerotic plaque.

What do we do?

Put it in the box in the basement.

Wow.

And so there's all this like, well, yes, those details are true, but...

The plaque's gonna bulge out this way instead of this way because your body tries not to narrow the blood vessel because you do need the blood flow, right?

So it's almost never the case that the plaque is just squeezing the blood vessel shut.

What happens is the inflammatory process inside the plaque

which is especially driven by the seed oils oxidizing in there and going rancid.