David Friedberg
speaker
8,052 appearances
60 recordings
4 series
first heard Apr 2024
last heard 21 Aug
David Friedberg’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 32 in all, peaking in Jan 2026 with 6.
Appearances
And they've reached a major agreement with the FDA to be the first company to treat humans with Yamanaka factors.
Specifically what they're doing is they're going to be delivering these Yamanaka factors.
These are these proteins.
that rejuvenate cells and make them youthful again into the eye.
And so their first indication is to actually inject them into the vitriol fluid in the eyeball, and they'll affect the retina in the eye to address people that have gotten blind from glaucoma or one of these kind of stroke-like diseases that happen in the eye.
And the expectation with this phase one clinical trial is that the delivery of these Yamanaka factors into the eye
will rejuvenate the retina, make it youthful again, and restore vision.
If it works, which it's expected to, because we see this result happen in animal models, it could be an extraordinary breakthrough, not just in terms of blindness, but in terms of the first human application of Yamanaka factors to reverse aging.
The way they're doing it is they're actually packaging up DNA that will make these proteins into viruses, AAV virus, that is delivered into the eye.
The virus will then go into the retinal cells and then will deliver this payload for this DNA to make these proteins in the eye cells.
And it can be turned on and off.
Amazingly, they've created a switch mechanism in it
where the protein production, the production of these Yamanaka factors can be turned on and off by taking an antibiotic called doxycycline.
So the person that gets the delivery of this drug takes the antibiotic, turns on the production of these Yamanaka factors, and then theoretically their eye cells will de-age, will get youthful, and their vision will be restored.
So phase one clinical trials underway first time in human history, we're seeing Yamanaka factors being delivered into humans, literally the tip of the iceberg.
There are now over a dozen startups that are trying to deliver Yamanaka factors, which are these proteins or some other sort of protein that can actually reverse aging by restoring the epigenome and cells and make them young again.
So this is the beginning of a wave of what I think will be the most extraordinary revolution in human therapeutics, and ultimately could lead to, you know, some people would argue the fountain of youth.
Is this just a talk study?
So is it mechanism?
Yeah, well, they'll see results.
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