David Ghiyam

We get back to the change between the good and the bad microglia, and that threatens neurons.

We get back to the change between the good and the bad microglia, and that threatens neurons.

he's saying the research is showing more of that now i don't know if that's 100 what he was talking about or something well i think that what he's saying is that there's more research coming out indicating that the period of uh fasting doesn't need to be as great so this is um you know not uh i i would say that this is really more of a discussion of what is called time restricted eating as opposed to specifically fasting

he's saying the research is showing more of that now i don't know if that's 100 what he was talking about or something well i think that what he's saying is that there's more research coming out indicating that the period of uh fasting doesn't need to be as great so this is um you know not uh i i would say that this is really more of a discussion of what is called time restricted eating as opposed to specifically fasting

you know those are kind of a bit nebulous terms when you say time restricted eating how much time when you say fasting is it three days is it 12 hours and i think it's kind of an analog scale i i to that probably 16 to 18 hours is going to be better than 12 hours but there's benefit to a 12-hour fast.

you know those are kind of a bit nebulous terms when you say time restricted eating how much time when you say fasting is it three days is it 12 hours and i think it's kind of an analog scale i i to that probably 16 to 18 hours is going to be better than 12 hours but there's benefit to a 12-hour fast.

And that is, or at least restricting your consumption of calories or other parameters as it relates to food, anything but water. There's been a discussion, well, is the morning coffee, even if it's black, did you break your fast? Right.

And that is, or at least restricting your consumption of calories or other parameters as it relates to food, anything but water. There's been a discussion, well, is the morning coffee, even if it's black, did you break your fast? Right.

No, nothing. I'm still on the clock. Yeah, yeah. But that said, this remains in evolution, and I think that there's more to come.

No, nothing. I'm still on the clock. Yeah, yeah. But that said, this remains in evolution, and I think that there's more to come.

And it's really quite exciting that we have researchers like Valter Longo who are looking at the implications of these types of interventions, which are fairly simple to employ, not only as it relates to longevity parameters, but also in his work as it relates to even the immune system vis-a-vis cancer.

And it's really quite exciting that we have researchers like Valter Longo who are looking at the implications of these types of interventions, which are fairly simple to employ, not only as it relates to longevity parameters, but also in his work as it relates to even the immune system vis-a-vis cancer.

So we're learning a lot that immunometabolism relates not only to these chronic metabolic diseases, Alzheimer's, but the function of the immune system as it relates to its ability to seek out and destroy cancer cells, for example.

So we're learning a lot that immunometabolism relates not only to these chronic metabolic diseases, Alzheimer's, but the function of the immune system as it relates to its ability to seek out and destroy cancer cells, for example.

Well, let me take a step back then, Lewis, if I could, because let's ask ourselves, how did we get to the GLP-1 discussion in the first place? Right.

Well, let me take a step back then, Lewis, if I could, because let's ask ourselves, how did we get to the GLP-1 discussion in the first place? Right.

Yeah, and it was through the lens of wanting to really unpack the fundamental role of metabolism in brain health. Yes, which metabolism is linked to mitochondria health. Right, mitochondria health. And I used the GLP-1 drugs as a way of really kind of supporting the notion that it's all about metabolic health.

Yeah, and it was through the lens of wanting to really unpack the fundamental role of metabolism in brain health. Yes, which metabolism is linked to mitochondria health. Right, mitochondria health. And I used the GLP-1 drugs as a way of really kind of supporting the notion that it's all about metabolic health.

Because these results are, for me, being at this for quite some time, I use the word astounding because they are. It is really the first time we're targeting the fire and not just the smoke.

Because these results are, for me, being at this for quite some time, I use the word astounding because they are. It is really the first time we're targeting the fire and not just the smoke.