David Thomas

speaker
92 appearances 1 recordings 1 series first heard Dec 2018 last heard Dec 2018

David Thomas’s voice in public audio — every appearance, attributed to the second.

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Yes.
So sarcomas are a rare group of cancers that affect predominantly a younger population.
They affect the connective tissues, bone, muscle, fat, cartilage, and so forth.
And they have a lethality of around 40%.
So six out of 10 people will survive a diagnosis.
So they're not nice cancers to get.
No,
with current treatment technology.
And there's lots of them, so they're not all the same.
No, so there are more than 50 different subtypes, which makes each individually ultra-rare.
In fact, in aggregate, they fit the definition of the Europeans and the Americans of rare cancers.
And that being rare makes gene hunting hard.
Yeah, that's right.
And they've been understudied also because they're rare.
And we got interested in understanding the genetics behind sarcomas because...
We cure them with surgery.
And so anything you can cure with surgery, the earlier you get it, the more likely you are to cure a patient.
So understanding the people who are at risk and detecting the cancers early is part of the holy grail of improving survival.
And you're part of an international group monitoring people with sarcoma, so you get large numbers.
Yeah, we're lucky enough to have started a study about 10 years ago now called the International Sarcoma Kindred Study.
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