Derek (More Plates More Dates)

One being minor CIRM activity potentially, and this is more speculative.

CIRM is like a selective estrogen receptor modulator, so something that...

binds to estrogen receptors and either like positively or negatively modulates them in selective tissues.

So there are certain tissues where it would be more favorable to have a selective inhibition of certain hormones versus others that would be detrimental.

Like you wouldn't want to inhibit estrogens activity in bone, for example, because that would cause bone degradation.

Having an inhibition at the hypothalamus level may, depending on the person, help increase testosterone via the inhibition of that feedback loop.

Now, I don't necessarily think it is a CIRM.

That's just like the tertiary potential mechanism, and it is speculative.

The main mechanism that people seem to agree on that it does do, suppression of SHBG to some extent, as well as the upregulation of steroidogenesis

intratesticularly, so like locally upregulating, I believe it's steroidogenic acute regulatory protein that basically incorporates cholesterol into the mitochondria to actually undergo these enzymatic cleaving sequences that result in the production of testosterone locally.

So it seems to like help upregulate the process that actually

uh, enzymatically spits out testosterone essentially, uh, locally.

So that one seems to work well for individuals who have high SHBG levels or, um, potentially higher estrogen levels than they, you know, as otherwise fixable via basic lifestyle changes and whatnot.

Um, cause everyone has their own proportion of metabolism at the end of the day.

And it's not always going to be optimal, even if you have what is otherwise like a great diet and lifestyle.

Um,

But also it's just like, I think it's for people who have adequate, everything looks on paper to be sufficient, but their SHBG might be a bit high or they could use a little bit of a boost.

And it seems to work to the tune of 100 to 200 nanograms per deciliter for some people.

And it depends on how potent of a standardized extract you get.

You want to look for one that is HPLC tested for uricominone.