Menu
Sign In Search Podcasts Charts People & Topics Add Podcast API Pricing

Dominic D'Agostino

👤 Person
1314 total appearances

Appearances Over Time

Podcast Appearances

The Peter Attia Drive
#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.

And that bought chambers and microscopes and electrophysiology equipment.

The Peter Attia Drive
#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.

It allowed me to tinker in the lab.

The Peter Attia Drive
#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.

And in the process of tinkering, we just had some serendipitous discoveries with the cancer things and then just fundamental effects that happen in cells under high pressure oxygen emissions.

The Peter Attia Drive
#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.

nitrogen, helium, different gases.

The Peter Attia Drive
#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.

Very basic.

The Peter Attia Drive
#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.

So the Office of Navy Research has a 6.1 program, and that's basic science, and then 6.2, 6.3.

The Peter Attia Drive
#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.

And as I progressed in my career, I started working up from a cell-based system to animal models.

The Peter Attia Drive
#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.

Then it went to a pig model system.

The Peter Attia Drive
#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.

Now, essentially, we're doing the rat studies at Duke with human subjects that get inside a chamber.

The Peter Attia Drive
#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.

We get diaphragmatic, we get EEG, we have a line going into their arm that goes to like a mass spec to get blood gases, to do metabolomics.

The Peter Attia Drive
#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.

They're working a simulator, a flight simulator, they're exercising.

The Peter Attia Drive
#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.

It's water out immersion, so their body's underwater, but you get the

The Peter Attia Drive
#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.

hypovolemic effect of the fluid shift and things like that to simulate that dive.

The Peter Attia Drive
#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.

And then we push them to a seizure, believe it or not.

The Peter Attia Drive
#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.

So this got approved through an IRB, which is even more amazing than the Cahill study.

The Peter Attia Drive
#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.

But we pushed them to an EEG seizure to where we can see the seizure and then we decompress.

The Peter Attia Drive
#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.

So we look at latency to seizure under ketosis, dietary ketosis or supplemental ketosis or the combination.

The Peter Attia Drive
#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.

So those clinical trials, I'm co-investigator on it because it's being done at Duke.

The Peter Attia Drive
#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.

They're registered clinical trials on clinicaltrial.gov.

The Peter Attia Drive
#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.

And these are being funded by the DOD?