Dr. Adeel Khan
speaker
165 appearances
1 recordings
1 series
first heard Nov 2024
last heard Nov 2024
Dr. Adeel Khan’s voice in public audio — every appearance, attributed to the second.
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Shouldn't everyone be doing this? But it turns out when you make that old cell young again, it makes it almost embryonic in nature, which means it can cause cancer or tumors. So IPSCs, as they're called, or Yamanaka stem cells to honor Professor Yamanaka, they're great. But the problem is they have the risk of tumor genicity. And so we don't actually use them clinically yet.
uh there's a lot of work being done on it but it's still i think a few years away from clinical translation so that's why the new cells because we know they don't cause cancer and we know they're naturally occurring on the body so they have a lot more clinical translation than the yamanaka steps
Yeah, so about 10 to 15 times more are able to go into circulation. So there is still some that get trapped in the lungs, but Professor Dazao has shown work showing that it's, you know, it's not like two times more. We're talking an order of magnitude, like 10 times more are able to go into circulation. So it is still a big difference compared to standard MSCs.
Yeah, look, I just had an ALS patient I treated a couple of weeks ago and I was blown away because it was my first ALS patient I treated with new cells and she couldn't swallow because of the bulbar symptoms, you know, and now she can swallow. She can speak clearly. She was barely able to speak before. And that was just one IV. And I mean, it was pretty incredible to see.
Obviously, that's anecdotal, but the clinical trial that was done also showed, you know, some slowing of progression there. And we all know how devastating ALS is. And if there's something that can slow it down even, I think we just don't know the exact dosing for ALS yet. But I think for now, I think we can certainly say it can be helpful and it's not harmful.
And then for stroke, we can be much more kind of certain that they are going to have positive results because in stroke, for example, she showed that 30% of patients in the clinical trial were able to go back to full-time work when they were disabled. Like we're talking patients who are disabled.
And they're able to go back. Yeah, exactly. And they go back to full-time work. So now 30% of people and the other 70% still had significant clinical benefits and were able to get off. You know, we're- They weren't necessarily able to return to work, but a lot of them were able to get back to normal functioning of ADLs and IADLs and stuff like that, which is still a big deal.
And you know what the most interesting part was? 25% of the patients in the clinical trial had reversal of gray hair. And that was just like an accidental finding.
Yeah, well, I mean, I know it sounds, you almost sound like a used car salesman or something when you're like, this can treat everything, you know? But once you understand the physiology of chronic disease, as you do, you understand that there's certain hallmarks of aging and there's hallmarks of chronic disease that overlap.
So I'm not going to list all 12 of them because I'll bore people, but there's basically 12 hallmarks of aging. We've listed a few of them, mitochondrial dysfunction, you know, stem cell exhaustion. Yeah. Chronic inflammation, which is related to amino senescence. And, you know, there's lots of protein, like there's so many protein misfolding. There's so many other ones.
And so basically these 12, let's call them the 12 hallmarks. They actually underlie not just aging, which is, you know, arguably the most complex chronic disease. They underlie all chronic diseases from stroke, from heart disease to asthma, to dementia, to cancer even, and just components of that that are overlying. And a lot of them are metabolic in nature.
And so that's why these stem cells have this ability to restore metabolic health because of that mitochondrial DNA transfer and helping to repair the mitochondria through mitophagy. And then, of course, the mitochondria are the ones that help to regulate metabolism, right?
That's where they have, that's where your, when you eat food and your body has to process it, it has to go through your mitochondria to produce energy. And if your mitochondria aren't working properly, which is what happens to everyone with aging and chronic disease, then guess what? Your metabolism is messed up.
And that's why metabolic disease is really the root cause of so many different problems. And that's why they call, you know, dementia type 3 diabetes. And all this other stuff, right? Because a lot of them are metabolic in nature. And if you can restore metabolic health, which stem cells can do, then that's why you can treat so many chronic diseases. And that's number one.
And number two, the other beauty of these stem cells is their ability to regulate your immune system. So this is called immunomodulation. That's the medical term, but that just basically means we're shifting your body from a pro-inflammatory state to an anti-inflammatory state. So this is called immunomodulation, which is reprogramming your immune cells, specifically your macrophages.
And if there's one cell that you need to understand, it's your macrophages. They're my favorite cell in the body.
Exactly. So they're like your little Pac-Man controlling and surveilling and making sure the bad guys don't get in and they eat the bad guys when they're around. They take them away and they'll dispose of them. But what happens to a lot of Pac-Men or police officers, I like to call them, is they get fat and tired. And then they start eating too many donuts and they can't do their job anymore.
And this is actually called lipid associated macrophages or LAMs. And so they accumulate fat and lipid perioxidation inside of the macrophage, and then they can't do their job anymore, and their job is so important. And then they start releasing the wrong signals. So the macrophages start releasing pro-inflammatory signals, and then that causes the cycle of chronic inflammation.
And that's really the root, as we know, of so many disease processes. And that's why if you can treat chronic inflammation, you can treat so many different chronic diseases. And that's why these IV mu cells have so much potential. And even with IV,
let's call it the first generation even with the iv you know first generation stem cells there are clinical trials that are published showing that inflammatory bowel disease can get into remission that rheumatoid arthritis can get into remission it's just the dosing is quite high and people need a lot of frequency of those but with the new cells you can get obviously you can get a lot better results but it's the same principle which is you're just regulating the immune system
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