Dr. Allen Bookatz

speaker

1,037 appearances 12 recordings 1 series first heard May 2026 last heard 3d ago

Dr. Allen Bookatz’s voice in public audio — every appearance, attributed to the second.

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Recordings per month over the last 12 months — 12 in all, peaking in Sep 2026 with 4.

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Health Optimization Medicine Podcast · Read Your Genes! APOE4, Brain Health, and Longevity | HOMe Podcast #026 · 9 Sep 2026 podcast

Well, we're gonna measure and we want to unburden the cell environment.

So first we establish the baseline phenotype.

And we do that by measuring things like organic acids, lipid peroxidation markers, NAD plush salvage metabolites and pathways, vascular markers, and circadian sleepwake parameters.

And so really talking to the person, getting a sense like what is.

what is their lifestyle like?

Then we want to identify and reduce the exposomic stressors.

So things like the lipophilic toxins, chronic nighttime light pollution, and those unmanaged glycemic variability.

Hint hint nighttime snacking.

Yeah, that's definitely fair and it's an important objection.

And I think when we understand what penetrance means, at least in this case, high penetrance is the means basically that the biological slope itself is steep.

So while we don't claim that lifestyle advice alone halts the progression to advanced pathology, and no one's claiming that here, but lifestyle advice becomes precision medicine when cell health

health markers guide the prescription.

By optimizing the mitochondrial bioenergetics, vascular integrity, and circadian NAD salvage pathways, we improve the cellular terrain in which that genetic risk operates.

Okay.

So your genotype is not your biography.

So one copy of this Apo E4 certainly raises risk.

Two copies increases the penetrance.

So phenotype early instead of being fatalistic here.

Dr.

Ted, you get

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