Dr. Allen Bookatz

speaker

1,037 appearances 12 recordings 1 series first heard May 2026 last heard 3d ago

Dr. Allen Bookatz’s voice in public audio — every appearance, attributed to the second.

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recordings per month · last 12 months

Recordings per month over the last 12 months — 12 in all, peaking in Sep 2026 with 4.

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Health Optimization Medicine Podcast · Can Creatine Protect the Brain from Sleep Deprivation? | HOMe Podcast #024 · 26 Aug 2026 podcast

caffeine, modafinil, or worse. matched

So as health optimization practitioners, we ask a different question. matched

Functional medicine focuses on pathogenesis, right? matched

That's hunting for the root causes of disease, like chasing adrenal fatigue or neurotransmitter depletion once the patient's already crashing. matched

Health optimization medicine focuses on cell ludogenesis. matched

These are words you're going to continue to hear here. matched

The root cause of health and cell energy. matched

Root cause isn't enough if the root question is still disease. matched

What we want to know is, how do we hold the cell's energetic dynamic equilibrium in real time, even when something like sleep loss is threatening it? matched

Yeah. matched

And Scott, that tracks like with what we see in acute trauma. matched

Under sleep deprivation, the brain's microglia, its resident immune cells, they shift into this defensive inflammatory posture. matched

And the astrocytes that feed neurons start failing to move lactate where it's needed. matched

So the frontal lobe, the most energy hungry part of the brain and the seat of our executive function, it runs out of ATP. matched

And it tips into that cellular acidification that Dr. Guip was talking about because it's stuck on running onto that anaerobic glycolysis. matched

I think of it like when we're doing heavy weightlifting, we're going into anaerobic exercise. matched

It's the same thing, but happening in the brain. matched

But we give it creatine and it doesn't just sit there as a buffer. matched

It ends up becoming an immediate ATP donor. matched

through the creatine kinase reaction. matched

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