Dr. Allen Bookatz

speaker

1,037 appearances 12 recordings 1 series first heard May 2026 last heard 2d ago

Dr. Allen Bookatz’s voice in public audio — every appearance, attributed to the second.

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recordings per month · last 12 months

Recordings per month over the last 12 months — 12 in all, peaking in Sep 2026 with 4.

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Health Optimization Medicine Podcast · Unlock Your Brain with Better Glymphatic Clearance | HOMe Podcast #028 · 23 Sep 2026 podcast

I kind of think of the vascular end feet as like sphincters, you know?

so, you know, when your sympathetic tone or sphincter tone is high, then it would make sense that, you know, any type of flushing out stops.

Okay, so the clearance runs like an overnight crew here.

And they only sort of get in when the building empties and the workers are all gone.

So the day workers are all gone.

So in a healthy chronobiological state, the cerebrospinal fluid or CSF, it enters the brain parenchyma through these peri-arterial spaces that are driven by cardiac pulsation.

So every time your heart pumps, it squeezes through these little channels here.

And it exchanges with this interstitial fluid collecting metabolic waste.

And so things like beta amyloid, tau, tau proteins, and cellular metabolites, those exit then those perivenous channels into the lymphatics in the dural system.

And so the aquaporin-4 channels at those astrocyte end feet, they make the flux fast enough to even matter.

here?

I'm glad, really glad you took us to the microclia, Jody, because it lands us on our third mandatory comparative reframe here.

So anti-aging medicine versus home hope, peak healthspan.

So anti-aging medicine, we know it focuses on lifespan extension.

So stretching those chronological years to the very, very end.

of what's possible for a human.

So regardless of what cell quality or tissue quality we're talking about.

So that's not wrong.

It just, it's not necessarily complete here, right?

We don't care about just extending the actual lifespan.

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