Dr. Andrea Love

speaker
239 appearances 2 recordings 2 series first heard Apr 2025 last heard May 2025

Dr. Andrea Love’s voice in public audio — every appearance, attributed to the second.

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She thinks I'm a paid shill because I'm defending chemicals. I'm curious.
Welcome to the Checkup Podcast. On this episode, we're answering a simple but loaded question. Are the everyday chemicals in our food, water and homes truly wrecking our health?
I'm Andrea Love. I have a PhD in Microbiology and Immunology. I specialized... Previously in academic research in infectious disease immunology, so understanding host response to infection and how the immune system mediates symptoms and resolution of infection. I now work in life sciences biotech, where I focus on
Technologies and Assays for preclinical, translational and clinical research for vaccine development, cancer, immunotherapy, cell and gene therapy, pretty much anything related to biomedical science. And I also do science communication through Immunologic. Cool.
Ja, das ist eine tolle Frage und ich denke, dass es wirklich die Konfliktion dieses Themas unterschätzt und es ist etwas, das wirklich prävalent ist in den sozialen Medien und der Influencer-Industrie, weil wenn wir über Autoimmunsysteme sprechen, gibt es über 90 verschiedene Autoimmunsysteme und sie sind alle... Das ist unglaublich multifaktorisch, richtig?
Und ein Rheumatologen handelt nur von Knie-Tissue, Rheumatologen-Disordern, die nicht die Skope aller Autoimmunität sind. Das wäre mehr unter der Skope eines klinischen Immunologen. Aber wenn wir über Autoimmun-Disordern sprechen, haben wir ziemlich gute Daten über einige der Beiträge zu vielen dieser. Und We have pretty good data about ways to manage these types of conditions.
But the hallmark or the central theme of autoimmune disorders are that your immune system, which normally should tolerate certain self.
Antigens Antigens are proteins or molecules that are present normally should ignore them and that establishes a feature of tolerance meaning it encounters things on your cells or things that you ingest the same reason that food allergies are not nearly as widespread as they could be theoretically because your immune system encounters them and it's like hey I don't need to have a reaction to that because this is something benign
In certain instances that is not the case and that immune response leads to an inflammatory cascade where inflammatory chemicals are produced, it recruits and activates a variety of different immune cells and these are going to be different depending on what type of autoimmune disorder we're talking about and that can lead to tissue damage or cellular damage and
Veränderungen in der Funktion einer Person, richtig?
Also, es gibt keine einzige Antwort, richtig? Es gibt viele verschiedene Beiträge dazu. We know that there are certain viral infections that are players in this. So there are certain types of viruses that can establish latency after primary infection.
And that means that they while you recover from the illness and the infection itself, the virus, because of the nature of the genetics of it, can actually exist in your body, kind of hanging out indefinitely until something happens. And what that something might be, it's going to be different. Depending on the person. Sometimes it's an acute immunosuppression.
Like say they're a solid organ transplant recipient and they have to take immunosuppressant medication so they don't reject the organ. That could elicit something. There are, and there's a variety of different types of viruses that are associated with that. Some of the herpes viruses, some of the papillomaviruses.
Genau, das ist ein Herpes-Virus. Diese können die Latenz im Körper erzeugen. Das Epstein-Barr-Virus ist auch ein Herpes-Virus und das hat mit der Entwicklung von Multiple Sklerose zu tun. Aber es gibt auch andere, wo es ziemlich idiopathisch ist und wir genau nicht wissen, was es enthält.
Besonders wenn wir über Dinge wie Type 1 Diabetes sprechen, was ein Autoimmunsystem ist, wo eure pancreatischen Blutzellen zerstört werden und somit keine Insulin mehr produziert werden kann. Das ist eine sehr andere Pathologie als etwas wie Vitiligo, wo dein Immunsystem die Melanocytes in deiner Haut zerstört, lediglich zu dieser patchigen Pigmentation.
Die Art und Weise, wie du diese Dinge behandeln wunderschön anders. Und das ist wirklich der Grund, warum du Autoimmunsysteme nicht in einem einzigen Bucket lösen kannst. We also know that there's some gender specificity. Women are about two times higher, more likely to develop certain autoimmune disorders than others. It's not all autoimmune disorders.
There appears to be a role in endocrine signaling, hormone signaling in that. That's also why we see... The majority of autoimmune disorders present during kind of middle age, where you start to see kind of increased. But a lot of changes in diagnosis or increased rates or increased prevalence is not necessarily because these things are actually happening more frequently.
It's because we actually know how to characterize them better, how to identify these types of diseases. Wir hatten keine Diagnostik-Tools, keine klinischen Kriterien. Und weil die Symptome oft nebulös sind oder nicht unbedingt mit einander verbunden sind, ist es wirklich schwer, ein Label darauf zu setzen.
Und deshalb ist es das gleiche Thema, das wir mit Autismus-Spektrum-Disordern sprechen, wo wir Rates in Bezug auf Diagnosen erhöhen sehen, was eine erhöhte Prävalenz bedeutet. Aber es ist nicht so, dass... more autism is necessarily happening.
It's because the criteria, the clinical criteria, the scope of how you can recognize and diagnose and then manage it is better because we understand more about those diseases. Interesting.
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