Dr. Ben Bikman

So this results in what people colloquially just call ozempic burps, where they just have putrid breath and burping and just stomach nausea.

But because of the change in gastric

emptying even some medications like birth control medications don't work anymore for example because you've so changed how long it takes that drug to get from the stomach into the small intestine where it would have been absorbed so it starts to change the absorption of certain compounds and drugs

as well as potentially affecting the absorption of nutrients which may be part of what the person is observing with regards to other changes in say muscle mass maybe that's a result of just poor nutrition because even though they're eating they might not be getting they might not be digesting and absorbing everything they're eating anymore because of how the the rate of the the peristalsis has changed so much so anyway numerous changes of the guts

And then there's a central nervous system effect to activate satiety centers.

Now, the combination of those two is powerful where you have the I'm full signal here and I have a lot of stuff in my stomach here resulting in a person who has a much better control over their appetite, I guess, to say that a polite way or to say that another way they just don't have as much of an interest in eating.

So that's the main mechanism of action.

And GLP-1 is a normal hormone.

I didn't mention this.

GLP-1 is a naturally produced hormone from the gut.

We have it.

We know that we can change its levels based on what we eat.

And that might explain why some people eat more or some people eat less.

But still, my concern is that the dose of GLP-1 that we're using now has gone.

It's just a little too much of a good thing.

Yeah, yeah.

So I think that the commonly used doses are going to be in the order of, actually in this case, I know it in milligrams, I think it's about five milligrams.

or so two and a half plus milligrams and a once weekly injection.

And if people are thinking of that in units, I think that's going to correspond to units of about 25 to 30 units of GLP one.

So that to me is too high.