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Dr. Craig Koniver

๐Ÿ‘ค Speaker
906 total appearances

Appearances Over Time

Podcast Appearances

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

You know, people don't always get there as quickly, but people get there with their sleep. Love it. And you compound it with glycine? Yeah. What's the rationale there? I really like glycine as an inhibitory neurotransmitter. It's calming to the nervous system over the years. I tend to start with that when people are having trouble settling down at night.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

You know, people don't always get there as quickly, but people get there with their sleep. Love it. And you compound it with glycine? Yeah. What's the rationale there? I really like glycine as an inhibitory neurotransmitter. It's calming to the nervous system over the years. I tend to start with that when people are having trouble settling down at night.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

You know, people don't always get there as quickly, but people get there with their sleep. Love it. And you compound it with glycine? Yeah. What's the rationale there? I really like glycine as an inhibitory neurotransmitter. It's calming to the nervous system over the years. I tend to start with that when people are having trouble settling down at night.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

Not that it's going to sedate people, but just transitioning from being active. You know, 8 p.m., 9 p.m., wanting to settle down, glycine in pretty large dosages, at least most people think they are, starting with 3,000 or 5,000 milligrams orally, kind of tones down the nervous system. People relax a little bit, and then they tend to sleep better from it. And then you can dial it up.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

Not that it's going to sedate people, but just transitioning from being active. You know, 8 p.m., 9 p.m., wanting to settle down, glycine in pretty large dosages, at least most people think they are, starting with 3,000 or 5,000 milligrams orally, kind of tones down the nervous system. People relax a little bit, and then they tend to sleep better from it. And then you can dial it up.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

Not that it's going to sedate people, but just transitioning from being active. You know, 8 p.m., 9 p.m., wanting to settle down, glycine in pretty large dosages, at least most people think they are, starting with 3,000 or 5,000 milligrams orally, kind of tones down the nervous system. People relax a little bit, and then they tend to sleep better from it. And then you can dial it up.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

Mold's become super big. Yeah, big. Yeah, I mean, it's very prevalent and it seems the more we talk about it, I mean, we've seen it for years and years and years. It makes sense, right? Like if you think about the amount of airplanes flying above us every day, pouring down heavy metals. I mean, it's massive. It's in the air, it's in the water, it's in the soil.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

Mold's become super big. Yeah, big. Yeah, I mean, it's very prevalent and it seems the more we talk about it, I mean, we've seen it for years and years and years. It makes sense, right? Like if you think about the amount of airplanes flying above us every day, pouring down heavy metals. I mean, it's massive. It's in the air, it's in the water, it's in the soil.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

Mold's become super big. Yeah, big. Yeah, I mean, it's very prevalent and it seems the more we talk about it, I mean, we've seen it for years and years and years. It makes sense, right? Like if you think about the amount of airplanes flying above us every day, pouring down heavy metals. I mean, it's massive. It's in the air, it's in the water, it's in the soil.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

You talk about glyphosate or Roundup, same exact thing. So many chemicals and it's challenging for us as humans. The way I break it down, not to get too far off topic, is we're water-soluble organisms living in a fat-soluble world. It's the job of our liver

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

You talk about glyphosate or Roundup, same exact thing. So many chemicals and it's challenging for us as humans. The way I break it down, not to get too far off topic, is we're water-soluble organisms living in a fat-soluble world. It's the job of our liver

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

You talk about glyphosate or Roundup, same exact thing. So many chemicals and it's challenging for us as humans. The way I break it down, not to get too far off topic, is we're water-soluble organisms living in a fat-soluble world. It's the job of our liver

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

essentially to take the fat soluble stuff make it water soluble so we can excrete it right and that takes place in the liver in two phases phase one we're using the p450 enzymes like taking the trash putting the trash in the trash can putting out the side of the road you have phase two amino acid conjugation the trash truck comes and picks up the trash very few things in nature induce phase two independent of phase one meaning most of us have trash piled up on the side of our road

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

essentially to take the fat soluble stuff make it water soluble so we can excrete it right and that takes place in the liver in two phases phase one we're using the p450 enzymes like taking the trash putting the trash in the trash can putting out the side of the road you have phase two amino acid conjugation the trash truck comes and picks up the trash very few things in nature induce phase two independent of phase one meaning most of us have trash piled up on the side of our road

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

essentially to take the fat soluble stuff make it water soluble so we can excrete it right and that takes place in the liver in two phases phase one we're using the p450 enzymes like taking the trash putting the trash in the trash can putting out the side of the road you have phase two amino acid conjugation the trash truck comes and picks up the trash very few things in nature induce phase two independent of phase one meaning most of us have trash piled up on the side of our road

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

Those things are the polyphenols, right? And so things like the blues, the reds, the pigments. That's why it's important to eat a wide variety of colors in your diet. Matcha tea has a very strong inducing effect on phase two liver activity. Is that right? Yeah. I need to develop a taste for matcha. Yeah. I feel like it's kind of grainy. It is, and it's bitter.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

Those things are the polyphenols, right? And so things like the blues, the reds, the pigments. That's why it's important to eat a wide variety of colors in your diet. Matcha tea has a very strong inducing effect on phase two liver activity. Is that right? Yeah. I need to develop a taste for matcha. Yeah. I feel like it's kind of grainy. It is, and it's bitter.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

Those things are the polyphenols, right? And so things like the blues, the reds, the pigments. That's why it's important to eat a wide variety of colors in your diet. Matcha tea has a very strong inducing effect on phase two liver activity. Is that right? Yeah. I need to develop a taste for matcha. Yeah. I feel like it's kind of grainy. It is, and it's bitter.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

But bitter things tend to be, again, helping that phase two. Glutathione helps phase two. We do a lot of that intravenously. And then glycine. is a wonderful agent for inducing phase two independent of phase one. And the trouble is, I don't think people realize, you know, people are told, well, you know, most pharmaceuticals induce a P450 enzyme.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

But bitter things tend to be, again, helping that phase two. Glutathione helps phase two. We do a lot of that intravenously. And then glycine. is a wonderful agent for inducing phase two independent of phase one. And the trouble is, I don't think people realize, you know, people are told, well, you know, most pharmaceuticals induce a P450 enzyme.