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Dr. Craig Koniver

๐Ÿ‘ค Speaker
906 total appearances

Appearances Over Time

Podcast Appearances

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

But bitter things tend to be, again, helping that phase two. Glutathione helps phase two. We do a lot of that intravenously. And then glycine. is a wonderful agent for inducing phase two independent of phase one. And the trouble is, I don't think people realize, you know, people are told, well, you know, most pharmaceuticals induce a P450 enzyme.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

And a misconception is, well, if I'm just inducing one, I'm good. If you induce one, you induce them all. So if you take any pharmaceutical, you're inducing your entire P450 system. You're speeding it up, meaning you're putting more trash out on the side of the road. And if you look at the amount of things we're being exposed to outside of pharmaceuticals, it's mounting. It's crazy.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

And a misconception is, well, if I'm just inducing one, I'm good. If you induce one, you induce them all. So if you take any pharmaceutical, you're inducing your entire P450 system. You're speeding it up, meaning you're putting more trash out on the side of the road. And if you look at the amount of things we're being exposed to outside of pharmaceuticals, it's mounting. It's crazy.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

And a misconception is, well, if I'm just inducing one, I'm good. If you induce one, you induce them all. So if you take any pharmaceutical, you're inducing your entire P450 system. You're speeding it up, meaning you're putting more trash out on the side of the road. And if you look at the amount of things we're being exposed to outside of pharmaceuticals, it's mounting. It's crazy.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

Yeah, that's what I'm saying. I'm just using that as a metaphor. Yeah, yeah, yeah.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

Yeah, that's what I'm saying. I'm just using that as a metaphor. Yeah, yeah, yeah.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

Yeah, that's what I'm saying. I'm just using that as a metaphor. Yeah, yeah, yeah.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

Right. The trash, again, very oversimplification. You need to speed up phase two to get the trash trucks come to pick up the trash so that you can then take that compound and excrete it in your stool, in your urine, your sweat, your breath. I mean, it's the only way it works. It's not complicated per se, but I think there's a lot of misconceptions about it.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

Right. The trash, again, very oversimplification. You need to speed up phase two to get the trash trucks come to pick up the trash so that you can then take that compound and excrete it in your stool, in your urine, your sweat, your breath. I mean, it's the only way it works. It's not complicated per se, but I think there's a lot of misconceptions about it.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

Right. The trash, again, very oversimplification. You need to speed up phase two to get the trash trucks come to pick up the trash so that you can then take that compound and excrete it in your stool, in your urine, your sweat, your breath. I mean, it's the only way it works. It's not complicated per se, but I think there's a lot of misconceptions about it.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

They can. Yeah, glycine is absorbed well orally. It has a really sweet taste. It's actually the smallest amino acid. A huge fan of it. We've been using it a long time. You can take big dosages of it. Very sick. Again, my starting dose is usually three to five grams at bedtime. And then the way I do this, recommend it, is try that for a few nights in a row.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

They can. Yeah, glycine is absorbed well orally. It has a really sweet taste. It's actually the smallest amino acid. A huge fan of it. We've been using it a long time. You can take big dosages of it. Very sick. Again, my starting dose is usually three to five grams at bedtime. And then the way I do this, recommend it, is try that for a few nights in a row.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

They can. Yeah, glycine is absorbed well orally. It has a really sweet taste. It's actually the smallest amino acid. A huge fan of it. We've been using it a long time. You can take big dosages of it. Very sick. Again, my starting dose is usually three to five grams at bedtime. And then the way I do this, recommend it, is try that for a few nights in a row.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

You're not noticing a thing, double the dose. Go to 10 grams, literally. Most people at 10 grams of glycine will notice it. And again, it's not going to necessarily make you drowsy. You're not going to be sedated. But your nervous system is going to be toned down a little bit. It's going to help you fall asleep a little bit better.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

You're not noticing a thing, double the dose. Go to 10 grams, literally. Most people at 10 grams of glycine will notice it. And again, it's not going to necessarily make you drowsy. You're not going to be sedated. But your nervous system is going to be toned down a little bit. It's going to help you fall asleep a little bit better.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

You're not noticing a thing, double the dose. Go to 10 grams, literally. Most people at 10 grams of glycine will notice it. And again, it's not going to necessarily make you drowsy. You're not going to be sedated. But your nervous system is going to be toned down a little bit. It's going to help you fall asleep a little bit better.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

And then while you sleep, where a lot of this detoxification process starts working, you're going to be more efficient in how your liver works. Everything ties together. Right.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

And then while you sleep, where a lot of this detoxification process starts working, you're going to be more efficient in how your liver works. Everything ties together. Right.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

And then while you sleep, where a lot of this detoxification process starts working, you're going to be more efficient in how your liver works. Everything ties together. Right.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

There's these bioregulator peptides, which were developed by this Russian scientist, last name Korvinson, I think. Done a lot of research, actually. There's published research about it. I think Penelon's one of the ones that... They say we'll survive the stomach acid and get through the gut and be absorbed. So I think that's true. We've always used it as injectable.