Dr. Craig Koniver
speaker
302 appearances
1 recordings
1 series
first heard Oct 2024
last heard Oct 2024
Dr. Craig Koniver’s voice in public audio — every appearance, attributed to the second.
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One of those intermediate products, and the main one is something called NADH. That NADH is then shuttled to the mitochondrial membrane for, you know, this is the magic where we make the most ATP, and there's five different hubs, or we call cytochromes, right? And this is how I think about it, because I just like to simplify. Cytochrome one is where we use NADH.
And what the different hubs are doing is we're exchanging electrons for protons. And that's a kind of an electrical process. We're exchanging electrons for protons, going down the assembly line to eventually turn this wheel, the ATPase wheel, to make ATP. The way I understand it is the five different hubs, different nutrients hit them. So cytochrome 1 is NAD.
Cytochrome 2 is riboflavin, vitamin B2, and succinic acid. Cytochrome 3 is CoQ10, vitamin K2. Cytochrome 4 is methylene blue, which we can talk about. And then cytochrome 5 are things like magnesium, vitamin A, and copper. So if you're thinking about mitochondrial health, if you include any or better all of those, you're going to maximize how your mitochondria can work and make energy.
It's the strongest way to do it. And it's, again, not necessarily complicated. So when I think of CoQ10, and again, we use a lot of NAD, which we can talk about, where I think most people, the traffic congestion happens on cytochrome one, right?
And so when we give people or upregulate their NAD production, it's essentially we're allowing for more electron flow at cytochrome one, which has a downstream effect on the other cytochromes, so the traffic jam opens up. And now you can move electrons to exchange for protons and make way more ATP. But that's not true for everyone.
And so some people, it could be at cytochrome three with CoQ10, it could be at cytochrome two, A lot of people have cytochrome 4, which is, again, cytochrome, we call it cytochrome C oxidase, which is where methylene blue binds. But that's just a simplistic view. We just, people, we run into traffic jams, right? These electron flow gets stuck. We're just trying to open up the traffic jam.
For sure. And CoQ10 has been studied very safe, up to 2,400 milligrams a day, no harmful effects. Sometimes I'll take more, like I was telling you earlier, it's been dramatic for me with migraine headaches and basically reducing them to zero.
But it makes sense if you think about it, right? So if you took an antibiotic, right, like we can just an antibiotics can be very specific what it gets approved for in terms of like working against a specific bacteria. But then through clinical use and just experience, you know, we learned that, oh,
I can use doxycycline or a Z-Pak, azithromycin or whatever it is for a variety of bacterial infections that extend well beyond just what it's approved for. Well, that makes sense.
Exactly what happened with semiglutidinazempic, right? Approved for helping glucose utilization or lowering, you know, blood glucose in patients with type 2 diabetes. And they found through use only people were losing weight. Mm-hmm. And now it's become blockbuster. And we see it with, you know, things like, you know, repurposing drugs for cancer, right?
There's a lot of that going on, a lot of the repurposing. So, you know, doxycycline is a very common one that's used in cancer therapies, I think by sophisticated oncologists. I don't treat cancer, but by sophisticated oncologists to use things like doxycycline, metformin, mabendazole, which is an anti-parasitic drug, right, to help with cancer. That's amazing.
That's what happened with Ozempic. I mean, it's again, I write prescriptions. I think there's a time and place. I think it's challenging for me, though, right? And I think for a lot of physicians, it's become challenging operating in a paradigm
When we talk about chronic disease, which is essentially failing, I mean, and we all know this statistically, we're not making huge dents in heart disease, cancer, autoimmune disease, neurodegenerative. We're not at all, but we're spending exorbitant amounts of money. Right. And this is, you know, something that I had to learn over time.
And I don't know how I got into it, but when I started my practice. Back in 2006, I started, it was traditional family medicine practice, but I started using these nutritional IVs. And this is before hangover IVs, this is before it was popular. This is, you know, 20 years ago. And what I learned was that these nutritional IVs help people feel better quickly.
And I developed this model for my patients, which I think is a better model, which is I want to help people feel better first, like we were talking about earlier in this podcast. Because if I can get people to feel better first,
What we learned through COVID, and honestly, what I want to say to you, Andrew, which is really true, your podcast and what you do has been so successful at a time during the pandemic when people lost so much trust in people like me, right? People lost that trust of, what do I do? This is a scary time. I don't know what's going on.
And you guys come along, you in particular, providing this very stable, vetted information that people can trust and have a starting point and be like, this is what I want to do. Because health, one of the gifts of COVID was it put our health on the forefront of most people's mind and life. And so what you're doing is tremendous work.
And I can tell you personally, no, literally like as a physician, I am just, it's such an honor to be here and to talk to you because every day, every day my patients come to me and said, I heard this on the Huberman Lab podcast. What do you think of it? And I am not joking. And I love that.
I think it is awesome because people, one, taking their health seriously, but two, they have a stable resource that they can trust. The problem with physicians, and I'll tie this back in, is physicians are hard to trust, right? And it's this paternalistic model, which is, and that's how I was trained, which is, you know, you're going to do this because I'm going to tell you to do it, right?
And I remember being in medical school, which was in the 90s. And I can't remember the exact specifics of the study, but they would go, they did a study where they collected the trash outside of physicians' offices, found that greater than 30% of prescriptions written that day were thrown away. Greater than 30%. Wow. And I remember learning that and I was like, what is going on? By the patients.
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