Dr. Dale Bredesen
speaker
108 appearances
2 recordings
2 series
first heard Apr 2025
last heard May 2025
Dr. Dale Bredesen’s voice in public audio — every appearance, attributed to the second.
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Appearances
Dhru Purohit Show · How to Make It To 100 With A Sharp Brain And Good Mobility · 19 May 2025
podcast
And this is equally important. As long as your brain is saying, I am being assaulted, whether it's by organisms or or inflammations or whether it's by concern that, oh, my gosh, you're going to get fired from your job or some, you know, someone's pushing you to have something do by tonight and you're you're going to be up all night working on it.
I think about, you know, all the times as an intern when I was up two and three nights in a row without any sleep whatsoever and how horrible that was for me. So that sort of thing is going to give you a problem. So managing the stress and look, check your heart rate. Heart rate variability or HRV, easy to do. And let's see how you do for your age.
And by the way, notice, you can see your heart rate variability jump two or three fold by one minute of slow, deep breathing. It's striking. So telling your amygdala, I'm not dying, I'm not under that much stress, things are gonna be okay. And yeah, short periods of stress with resolution, fine. It's that chronic, oh my God, I've got something to do every day.
and just keep going, that's a problem. Then we've got brain training, and this is Professor Mike Merzenich, who is the father of brain training, who did a great job, started Posit Neuroscience, has developed BrainHQ, and has worked with Tom Brady and so many others who want to improve. In his case, it was improve his visual field, and it has worked very well for him.
So improving your cognition and reducing risk for decline, things like brain HQ and stimulation, and by the way, other forms of stimulation, photobiomodulation, great. Things like V-Lite and Neuronic and groups like that have done a really nice job. Mild stimulation in appropriate wavelengths and with appropriate frequencies has been very successful.
Absolutely.
Yeah, and your circadian rhythms, huge. And then there is detox. And again, you could spend a lot of time just talking about detox, but there are some basics from filtered water to your elimination, your sweating. The study that's always quoted out of Finland, people who did saunas six days a week versus those who only did them two days a week.
Huge issue, a huge difference in the risk for dementia for that group. So the people who did more saunas, much lower risk of dementia. And the effect was large. And then, so all these sorts of things for detox and making sure that you don't have exposure to toxins.
And again, to go back to Robert Lustig in his excellent book, Metabolical, much of the food that we eat really could not be classified as food. It should be classified as poison. because it doesn't have nutritive value and it does have toxicity in it. So as he pointed out, it's more correctly classified as poison.
And so just getting that detox, getting rid of that, getting on whole foods, plant-rich diet, very helpful. And then finally, some targeted supplements and improving your BDNF with things like whole coffee fruit extract, actually first mentioned to me years ago by David Perlmutter. So thanks to David for that. I think it was an excellent suggestion.
And many, many people, of course, have used that strategy. Of course, you can also increase it with things like exercise. And then for many of us, we're too low in magnesium, too low in zinc, too low in iodine, too low in potassium, making sure that those are optimized. Many of us are too low in choline and vitamin D as well. So making sure that we're okay there.
And then many of us too low in B12, for example, which will increase your homocysteine, which is again, another risk factor for cognitive decline.
I take it every day. Yes, absolutely.
Yeah. And again, you can check your RBC magnesium. So again, you kind of want to make sure that you are in the right range and an optimal range.
And it can be a life that will keep you from having cognitive decline until you're 100. I mean, that's our goal is to make everyone get to 100 with good cognition. And you're right. Look, if we just optimize their energetics, get them so that they're doing good exercise and that they have insulin sensitivity
and that they don't have chronic inflammation and don't have chronic stress, most people are gonna do very well. And then the few people who begin to have symptoms, do not wait. Do not let your doctor tell you it's normal aging because you don't have to have this with aging. Get in there, get evaluated, and then get optimized for those things.
And that way, most people won't need a lot of evaluation. They can do some basics and do quite well.
It's a growing problem. When I was training many years ago, we never saw people in their 40s, 50s. This was a disease of late 60s, 70s, 80s, 90s. Now, one of the most common things we see is people who are in their 40s or 50s who are getting diagnosed with Alzheimer's. So yes, we're getting a little better at diagnosing it for sure.
There are new blood tests, et cetera, but there's no question it is on the increase in these young groups.
It is possible. That's one of the many things, you know, we're hearing from RFK about all these different things. One of the issues is, what are we doing about metabolism? We do not have an optimum, as you know, we do not have an optimal metabolism in most people in this country. too much high-carb food, too much ultra-processed food, and a lot of damage, frankly, to our metabolic systems.
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