Dr. Dale Bredesen
speaker
108 appearances
2 recordings
2 series
first heard Apr 2025
last heard May 2025
Dr. Dale Bredesen’s voice in public audio — every appearance, attributed to the second.
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And so this is one of the possibilities. And there are other things as well. There are things you can do to avoid that. But improving your insulin sensitivity, of course, what Ozempic will do will increase your endogenous insulin as well. The problem, of course, is that there are some side effects, and we don't yet know the long-term effects of using GLP-1s.
Yeah, it's a great point because they're both. That's the problem. So they have one effect, which is to reduce the overall inflammation. And as I pointed out in the book, which as you know, this book is really about saving synapses for all of us.
You know, in the US, whether you live to 80, 90, 100, 110, of course, people are trying to push that up far to 140, 160, whatever it is, your lifespan, unfortunately, is not met often by your brain span. So you get to 40 or 50 or 60 and things just collapse, as you know. And so as you indicated, more young people having a problem.
So this is a time in which you've got to look at what are these different drivers and whether, so what'll happen with the statins? Yes, you lower the inflammation, which by the way, you can do with other things. You don't need statins to do that. But you also lower the support for the brain. You lower the cholesterol. And to be fair, you make some in the brain as well.
But if you use a statin, if you have to do that, and we recommend you do other things first. There are things like Zetia and Bergamot and just changing your diet and exercise. A lot of things you can do before you ever need statins. And there are also things beyond. PCSK9 inhibitors can be even better than this.
But if you're going to use a statin, use one that would be called a hydrophilic statin, that would be like a Crestor, instead of one that is a hydrophobic statin, which would be like a Lipitor.
Yeah, it's a great point. And for some people, it'll be okay. But here's the problem. When you have any sort of dairy can produce some degree of inflammation. So if you've got someone who already has some degree of cognitive decline, or if you're trying to optimize your brain span, then you want to take that into account. You want to get rid of grains, which can damage your lining of your gut.
You want to get rid of dairy. And it's not to say you can't slowly reintroduce it in the future. But you have to remember, when you see someone who's beginning to have some cognitive decline, only one of two things will happen. Either you will help them to improve, and we've published that many times, or they will die. They will go on to develop Alzheimer's disease and pass away.
So we want to do everything possible. We want to pull out all the stops to get the optimal reversal of cognitive decline. And we were the first to publish that back in 2014.
uh and so that does we want to do everything possible that includes getting rid of some grains that includes getting rid of dairy and includes getting rid of simple carbs and then you want to have a plant-rich mildly ketogenic diet you want to have appropriate exercise as you said and just go right down the list managing stress optimizing sleep these are things that people aren't doing when i ask people you know how much did you sleep last night what did your wearable show for your sleep
They don't know. So you want to have at least seven hours of sleep at night. You want to have at least an hour and a half of REM each night. You want to have at least one hour of deep sleep each night. And you want to have an oxygen concentration saturation in your blood of at least 94 percent while you're sleeping. So many people don't have that.
So they are getting this is why the brain span in America does not equal the lifespan in America. And that's something that clearly can be improved.
Yeah, it's a great point. So there's so much now for all of these things that we know that we didn't know even just a few years ago. So as you said, HIIT, this high intensity interval training has turned out to be the one that seems to be the most effective at reducing your risk for cognitive decline. But then beyond that, there are things like Katsu bands.
These are restriction bands you can put on your arms and your legs. And what they do is they actually give you more bang for your buck because what happens, Megan, is you get different mechanisms. So when you do strength training, you are improving your insulin sensitivity, which is critical for your brain and critical for preventing cognitive decline of Alzheimer's disease.
On the other hand, when you do the aerobic training, you are improving blood flow and oxygenation. This is one of the reasons something called EWOT is so helpful, which is exercise with oxygen therapy. EWOT gives you better blood flow and better oxygenation at the same time. So many people find this very helpful.
So there's a lot of new understanding about what works the best and what are things that are available to get best outcomes in that area.
So the big three are things that are in organics, and that would be things like air pollution, we know is a huge issue, and that's been published repeatedly as increasing risk for Alzheimer's disease. Here in California, the California fires, big issue. Also things like mercury amalgams, things like that. So those are all under the in organics.
Then these, the organics, and that's things like anesthetic agents. People have these long anesthetic procedures and then start to go downhill after that. So you need to detox from that. Things like benzene, toluene, glyphosate, all of those are in the organic group. And then finally the biotoxin group.
And again, this is something that hasn't even been recognized, hasn't been talked about nearly enough. There are biotoxins that we live with things like trichothecines and opratoxin A. And these are things that are typically made by different mold species. And as you know, Megan, one of the ones that's been talked about a lot lately on the organic part is microplastics.
There is increasing evidence that, number one, we're all exposed to these things. They're in the air, they're in the water, they're in the food, things like that. What we know now is that they concentrate in your brain. We are all exposed to and ingesting, on average, one credit card worth of microplastics each week. So the increase in our exposure has been dramatic.
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