Dr. Darren Candow

It sort of increases osteoblast cells.

These are the cells that sort of create or the formation of our bone cells.

So in rodents, osteoblast cells have been energized in the presence of creatine.

So it was logical to think in humans, maybe our osteoblast cells, the cells that are responsible for increasing bone size and strength,

might have more fuel, and these cells do use creatine just like our muscles do for fuel, and potentially increase bone density.

And if that's true, we've just cured osteoporosis, basically.

The other line of thinking, which is surprising, going back to this anti-catabolic phenomenon, is the best lines of evidence with bone are from an anti-catabolic perspective.

It seems to resemble a bisphosphonate.

So a lot of viewers are maybe taking a bisphosphonate.

It sort of preserves your skeleton.

I know my mom is taking that as well.

So creatine reduces something called the osteoclast activity or bone resorption.

So for some reason, it really inhibits these osteoclasts from sort of chopping down our bone and increasing blood calcium levels when not needed.

And then, of course, if it sort of increases osteoblasts potential, then

maybe the recycling of bone gets stronger.

It's kind of like laying a foundation of a house.

The bricks are stronger.

You're sort of putting the bricks together a little bit faster and then inclement weather is not chopping away the bricks or the cement.

So that's how we theorize it was working.

And there's been about 15 studies now showing that it has a lot of anti-resorptive effects.