Dr. David Perlmutter
speaker
585 appearances
1 recordings
1 series
first heard Jul 2026
last heard 15 Jul
Dr. David Perlmutter’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 1 in all, peaking in Jul 2026 with 1.
Appearances
Well, I want to make it as simple as I can because the reality is it's not that difficult.
There are so many of us that are out there really pretty much saying the same thing with nuances here and there.
But it's really all about the pillars, the adequate and restorative sleep, the exercise, the diet that keeps our blood sugar in check.
And connecting, like you said, grandparents connecting with children, connecting with other people.
Those are the pillars.
And in Brain Defenders, I deconstruct them quite a bit so that people can really get what is going on here in terms of its effects on the brain's immune system.
I think one of the major mechanisms that we should unpack a little bit is inflammation.
And that inflammation can be brought on by having a blood sugar.
For example, that's too high.
When our blood sugar is too high, it induces, strangely enough, inflammation in the body through a number of mechanisms.
When we bind that elevated blood sugar to our proteins, it's called glycosylation.
When we glycosylate our proteins,
because our blood sugar is too high, those proteins look a little bit foreign to the immune system and stimulates their activity so they create inflammation.
Inflammation creates chemicals that are called cytokines.
They get into the brain and shift our microglial cells
that is a bad thing that's what we want to avoid that's just one of the reasons that elevated blood sugar is an issue we talked about earlier about the function of insulin in the brain etc but we didn't you know it's good to understand that elevated blood sugar is an inroad to inflammation i think it's another mechanism that we really need to embrace and and really um
So much is said these days about the microbiome and how in the world could we be relating what we've been talking about, these microglial cells in the brain shifting to being threatening, how in the world could that relate to the microbiome?
Well, let me set the table a little bit and then we can talk about it.
We've now known for about 15 years that there are fairly distinct changes in the microbiome that characterize or at least are associated with Parkinson's and Alzheimer's and other neurodegenerative conditions.
We've seen that.
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