Dr. David Perlmutter

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585 appearances 1 recordings 1 series first heard Jul 2026 last heard 15 Jul

Dr. David Perlmutter’s voice in public audio — every appearance, attributed to the second.

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Recordings per month over the last 12 months — 1 in all, peaking in Jul 2026 with 1.

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Be Well by Kelly Leveque · 393: Alzheimer's Starts Decades Before Symptoms…Here's Why | David Perlmutter · 15 Jul 2026 podcast

and the 16S RNA evaluation of your microbiome as well as its metabolites and come up with an understanding of who you are and what are your needs.

But I'd like to look at the

What are the downstream manifestations of dysbiosis?

And to be clear, it's inflammation.

So we can look, you know, a simple test that I think is really effective is to look at either LPS, lipopolysaccharide levels themselves, or I think the Cyrix Laboratory offers this, something called LPS antibodies.

So LPS is the covering over certain bacteria that live in the gut called gram-negative organisms.

and it should remain in the gut.

If it gets across the barrier, it does two things.

Number one, it's telling you that the barrier is leaking.

Number two, the LPS is hugely pro-inflammatory.

So when we see elevated LPS, we know that there's a bump in inflammation in the body.

This directly affects the brain and directly affects the microglial cells.

They are sensitive to LPS levels in the bloodstream, and it will shift them.

You know, I tend to gravitate more in a general outreach approach in a book like this to simple things that people can get or may have already had, like the fasting blood sugars, insulin levels, C-reactive protein.

We do talk about it.

And we do talk about

more brain-centric type of laboratory studies like p tau 217. p tau 217 sounds uh really kind of technical but i'd like that your viewers to become familiar with p tau 217 phosphorylated tau 217 because it's a powerful marker

of early destruction of the synapses, of the way one neuron through its dendrites is connecting to the next.

And ultimately, that's what suffers in these neurodegenerative conditions is connection at a cellular level, for sure.

And at a macroscopic level, people who experience these issues lose connection with themselves and lose connection with others and ultimately with the world around them.

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