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Dr. Diego Bohórquez

👤 Speaker
956 total appearances

Appearances Over Time

Podcast Appearances

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

Yes, and then Professor Tony Sclafani, he had been studying these behaviors and he went in so far to suggest that perhaps the sodium glucose transporters are some of the ones that are detecting the sugar as it enters the intestine and that's what is causing the behavior.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

So we began working on the system and we wonder, could these cells,

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

be the ones that are guiding that behavior.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

And around the time that we published this work, Professor Charles Zucker at Columbia also further advanced that area by building on the previous work and demonstrated that there were a population of neurons in the brainstem that were integrating this information from the gut

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

And by that, the gut and the brain were guiding this behavior.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

Correct.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

And as I usually say, I call it instinctively because our mother doesn't have to teach us, hey, Diego, that is glucose, you know.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

It may present us in some ways, but at the end of the day, I have to go and get my glucose, get my amino acids, right?

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

Because eating is very simple.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

We're just trying to solve this issue of getting our carbons, getting our nitrogen, getting our phosphorus, our potassium, our sodium, and our chloride in so many different ways, shape, or forms, right?

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

So I went back to the experiment, the key experiment.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

So when we were able to put these opsins and bring the light and shut off these cells very rapidly, when we had presented the animal with a choice of sweetener over sugar, then all of a sudden the animal became blind to the solutions.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

It couldn't discern between the stevia, so to speak, or the sweetener from the actual sugar.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

The intestine.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

That's right.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

Right after the stomach.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

It's like just a small portion of the intestine.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

The conscious sweet taste.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

Which of you think about it?

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

It's not fully conscious, right?