Dr. Douglas Lucas
speaker
736 appearances
1 recordings
1 series
first heard Jul 2026
last heard 28 Jul
Dr. Douglas Lucas’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 1 in all, peaking in Jul 2026 with 1.
Appearances
So you know if we look at the estrogen levels throughout a woman's monthly cycle in the follicular phase, you see estrogen rise, right?
It goes much higher than any other time.
And then it drops, and then it kind of comes back up in the luteal phase, but the luteal phase is dominated by progesterone.
you see very clearly the effect of estrogen, right?
It slows down bone loss.
And so you'll see CTX rise during that time.
I'm sorry, you'll see CTX drop during that time.
And then during the luteal phase, you'll see it rise.
And you see this natural push-pull of the estrogen and progesterone dominance.
And so that is the natural cycle, this push-pull, this rhythm that's occurred every month during the cycling years of a woman.
that as you get into perimenopause, starts to get dysfunctional.
These women, especially if they stop ovulating, then you kind of don't have that progesterone rise.
And this is where this dysfunction starts.
So it has an effect on both sides of the metabolic equation.
So it has the most profound effect on CTX.
It does have an impact on osteoblast.
It's just not as obvious.
So we think that it supports osteoblasts, but really progesterone is more supportive of osteoblasts.
We see that osteoblasts have progesterone receptors, that natural push-pull of the rhythm of the estrogen and progesterone flow that will encourage osteoblasts to either go away or to come back.
Progesterone probably plays a bigger role than does estrogen, but it's not as well studied.
Showing 301–320 of 736 · page 16 of 37
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