Dr. Elissa Epel

So we're learning more and more, but we do know that they tend to secrete the cell like lets out fragments of mitochondrial DNA into the serum during acute stress. So that's not a good thing. That's not a good sign. That's a sign that our mitochondria are, you know, overstressed and responding to stress with with this excessive what we call cell free mitochondrial DNA. So they're outside.

Yes, I think that's exactly right. And that is a new area. In 2018, we published the first paper showing that chronic stress was related to lower mitochondria. And then we were like, why didn't we measure fatigue and vitality? Because you would imagine you have low mitochondria. Some had as low as people with mitochondrial disorder.

Yes, I think that's exactly right. And that is a new area. In 2018, we published the first paper showing that chronic stress was related to lower mitochondria. And then we were like, why didn't we measure fatigue and vitality? Because you would imagine you have low mitochondria. Some had as low as people with mitochondrial disorder.

Yes, I think that's exactly right. And that is a new area. In 2018, we published the first paper showing that chronic stress was related to lower mitochondria. And then we were like, why didn't we measure fatigue and vitality? Because you would imagine you have low mitochondria. Some had as low as people with mitochondrial disorder.

And that is thought to be at the center of both chronic illness and mental health now, these mitochondria as the source of aging, breakdown. And so I think it's really helpful to think of our mitochondria and what gives them a boost and boosting positive affect, having more of these restorative states, but also the hormetic stressors that they probably love them.

And that is thought to be at the center of both chronic illness and mental health now, these mitochondria as the source of aging, breakdown. And so I think it's really helpful to think of our mitochondria and what gives them a boost and boosting positive affect, having more of these restorative states, but also the hormetic stressors that they probably love them.

And that is thought to be at the center of both chronic illness and mental health now, these mitochondria as the source of aging, breakdown. And so I think it's really helpful to think of our mitochondria and what gives them a boost and boosting positive affect, having more of these restorative states, but also the hormetic stressors that they probably love them.

It's interesting to think of really planning regular, like a lifestyle habit, hormetic stress episodes. So they're, you know, it's very common to be doing ice exposure or sauna or Wim Hof breathing. And those are, I mean, to be totally honest, I don't think we have many options in our toolbox for hormetic stress that we know of and we know how to use safely and find the right dose.

It's interesting to think of really planning regular, like a lifestyle habit, hormetic stress episodes. So they're, you know, it's very common to be doing ice exposure or sauna or Wim Hof breathing. And those are, I mean, to be totally honest, I don't think we have many options in our toolbox for hormetic stress that we know of and we know how to use safely and find the right dose.

It's interesting to think of really planning regular, like a lifestyle habit, hormetic stress episodes. So they're, you know, it's very common to be doing ice exposure or sauna or Wim Hof breathing. And those are, I mean, to be totally honest, I don't think we have many options in our toolbox for hormetic stress that we know of and we know how to use safely and find the right dose.

So we're, people experiment and It's just a new cutting edge area of stress to really understand how these are affecting aging and mental health. There is exciting work on depression and hypothermia showing that when you can raise your core body temperature, even just a few sessions, it can lead to over a month of remission from more severe treatment-resistant depression.

So we're, people experiment and It's just a new cutting edge area of stress to really understand how these are affecting aging and mental health. There is exciting work on depression and hypothermia showing that when you can raise your core body temperature, even just a few sessions, it can lead to over a month of remission from more severe treatment-resistant depression.

So we're, people experiment and It's just a new cutting edge area of stress to really understand how these are affecting aging and mental health. There is exciting work on depression and hypothermia showing that when you can raise your core body temperature, even just a few sessions, it can lead to over a month of remission from more severe treatment-resistant depression.

And of course, the cardiovascular effects are well-documented. Rhonda Patrick just wrote a beautiful review of what repeated sauna does. Oh, wow.

And of course, the cardiovascular effects are well-documented. Rhonda Patrick just wrote a beautiful review of what repeated sauna does. Oh, wow.

And of course, the cardiovascular effects are well-documented. Rhonda Patrick just wrote a beautiful review of what repeated sauna does. Oh, wow.

I'll email that to you.

I'll email that to you.

I'll email that to you.

Yes, it is. And, you know, it's beautiful in that it's not medical. So it's doing it's, you know, creating all of these changes in the cell in a dramatic way. Same with cold exposure, same with breath holding, extreme breathing, and then the recovery response.