Dr Jay Jagannathan

speaker

177 appearances 1 recordings 1 series first heard Apr 2026 last heard 30 Apr

Dr Jay Jagannathan’s voice in public audio — every appearance, attributed to the second.

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Recordings per month over the last 12 months — 1 in all, peaking in Apr 2026 with 1.

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The Dr Louise Newson Podcast · 62 – How hormones change your brain - Dr Jay Jagannathan · 30 Apr 2026 podcast

Saltatory just means it's jumping.

So it tends to jump from node to node

along the myelin sheath, and that significantly increases the rate in which impulses are transmitted.

So understandably, if the myelin sheath is affected, which it can be affected both through hormonal changes, diseases, just multiple sclerosis, things like that, can affect it as well, that slows down the transmission.

And as I was mentioning, if you think of a nerve as a relay station that connects to millions of other relay stations in the body,

A damage, even to a small degree of the myelin sheath, can cause catastrophic repercussions when it occurs downstream.

It may not just be happening with one muscle.

It may be happening with millions of muscle fibers.

And that's why the myelination is important.

And as you mentioned, the hormonal changes can play a significant role in that.

Yeah, that's absolutely true.

And the other thing that's really interesting about that is men who've been on antiandrogen treatment have also been shown to have some increased risk of disease like MS.

And same actually, interestingly, with meningiomas too.

You know, it's kind of an interesting area because it's, you're right, it as much boils down to the testosterone as it does to the estrogen.

It's that balance, you know, and it's a very, very delicate balance that when it gets disrupted, you know, can have a significant ripple effects downstream.

Sure.

And yeah, I think those are extremely important points.

I think the other one point I really want to emphasize, we've talked so much about symptomatology related to hormones, about brain structure, about brain chemistry, because social media has a tendency to kind of

promulgate kind of myths.

The important thing to keep in mind is things like intelligence are not affected by these changes.

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