Dr. Jeff Bland

speaker

312 appearances 4 recordings 1 series first heard Nov 2024 last heard Jun 2025

Dr. Jeff Bland’s voice in public audio — every appearance, attributed to the second.

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The Dr. Hyman Show · How Jeff Bland Reversed His Biological Age at 79 (Part 1) · 28 May 2025 podcast

You know, I think that this thing that we call our life is a really fascinating opportunity, isn't it, of exploration. We're all kind of the explorers to figure out what our genes might be able to give us in terms of our ability to perform in the years that we call our life. As I've thought about this over the years, it's always been my belief that our genomic potential

for most people, and I would include myself in this, is probably greater than that that we're really doing in terms of our phenotype, how we look, act, and feel. So how do you maximize the genetic potential that lies within your genome to fully express the humanness that is within you and be the best person you can be.

Do you realize that when you are ill and your immune system is activated, that 50% of your metabolic energy is being consumed by your immune system? And how is it making its energy? Mitochondrial function. So if you have impaired mitochondrial function, your immune system is tired. It's worn out. It has immunosenescence. It's producing oxidants. It's creating free radical damage.

It's engaged with the reduction of longevity. And so mitochondrial health is intimately connected to immunological health. It's another part of that story. So this is why ultimately I landed six years ago on asking, what have I learned after 40 years of being in this field? If we want to talk about root cause, what is root cause? Where does it start?

And as you said, you can keep going up the tree. And I finally landed on the fact that there are only three places that our body is communicating with the outside world 365, 24-7. And those are the nervous system, the mucosal surfaces of our body, and our immune system. Those three areas are communicating continuously with the outside world and telling our inside body how to function.

And I said, well, now let me think about that.

And so you've got to think about how are we responding to the outside world through signals or through messages. And so when I went to that level, I said, okay, so let's look at that. You have the gut microbiome, you have the nervous system, and you have the immune system, all of which are intimately interrelated, one with the other, and are communicating with the outside and inside world.

Which of those is most able to change quickly? And then I recognize that the immune system turns over every 120 days. Every 120 days, our immune system are different cells than they were previously. Now just think of that for a moment. We're making over 2 million new white blood cells, immune cells, A minute. We are constantly reproducing our immune system.

So the question is, is it as good as, better, or worse than the cells that it's replacing? The answer to most people over life is it's worse. That's immunosenescence. Our immune system declines. So people say, oh, yeah.

Which can be more rapid than our number of birthdays.

That's exactly right.

And so then it begs the question, doesn't it, during SARS-CoV-2 infection, Why did we in the United States do more poorly than any other developed country in terms of intubation, hospitalization, death? And it was not because we're an older society. It was because we had the poorest immune state of vigilance. We were immunosenesced as a country.

And on our bodies, we're not able to manage the effective SARS spike protein. Yeah. as people in other countries that had a more vigilant, resilient immune system. And shame on us.

So it was absolutely just what you said that caused me to wake up one morning and say, maybe I need one more shot at the goal here. Maybe I need to really focus my attention. Now that we've gone through gastrointestinal restoration, now that we've gone through metabolic detoxification, now that we've gone through mitochondrial resuscitation, maybe we need immunorejuvenation.

Maybe we need to study how to rejuvenate the immune system. It's not boosting the immune system. We don't want to boost immune system that's imbalanced. That only makes it worse. We want to activate resilience and make it more functionally adaptive. And that is immunorejuvenation. So the cells that we replaced are better than the ones they came from, not worse.

And that becomes a whole different strategy. And when I hit on this idea, my colleagues, Annette Giardi and Trish Ury, who work with me now for 30 years, they said, Jeff, you know, you're a fairly big guy in stature. This is a pretty bold idea. So maybe you need one more company. Why don't we call it Big Bold Health?

And let's just go after this concept and see if we can't find a way of approaching how to rejuvenate the immune system. And lo and behold, the last five years, we're learning it. We're learning how to do that. And it's not just us, the whole field of immunology is changing. This whole immunological connection is now blossoming. It's revolutionary how fast things are changing.

I'm so excited that you asked this question. I'm so excited that you brought this up.

But it's shocking, you know? So no one has ever asked me this question, so I'm so excited about us talking about it. I asked you many years ago if you would become the editor of a journal that I had been writing for, Alternative Medicines in Health and Healing, in which you did a fantastic job as an editor.

The first issue of that magazine, that journal, I published a research paper that was on this very topic that you're talking about. And I'm very proud of this paper because it was the stake in the ground around this concept that you're describing, that you've developed so wonderfully over the decades.

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