Dr. Jeff Bland

speaker

312 appearances 4 recordings 1 series first heard Nov 2024 last heard Jun 2025

Dr. Jeff Bland’s voice in public audio — every appearance, attributed to the second.

Trend

recordings per month · last 12 months

No recordings in the last 12 months.Older appearances are listed below; set an alert to hear about the next one.

Appearances

newest first · ▶ plays the moment

The Dr. Hyman Show · How Jeff Bland Reversed His Biological Age at 79 (Part 1) · 28 May 2025 podcast

And what we did is we took a group – this is our little research center we had in Gig Harbor, Washington at the time. We studied – I think it was 80 people that we had – 30 of those people were on a kind of a standard of care. And then 50 of them were on an intervention program, like you've just described.

This kind of dietary program that was high in phytochemicals, but was low in allergic substances, was free of gluten, didn't have sugar. Dairy, yeah. Yeah, all those kind of things. And we followed them. And we were the first group, I think, ever to look at liver detoxification. Look at gut integrity using lactulose mannitol test to measure gut permeability. How to measure leaky gut. Exactly.

And we looked at caffeine clearance. We looked at benzoate excretion for liver phase one and phase two detoxifications and clinical symptoms over the course of, I think it was two months. Yeah. And we saw about a 60% reduction in symptoms of the treatment group versus the control group. And that was published in 1991. That was a foundational statement starting functional medicine at that point.

You have taken that and moved it to a much higher state of refinement. But I'm very, very... proud to say that what we were starting to understand, and I want to emphasize starting, that the gut was connected to the immune system. The immune system was connected to the liver. The liver has its own immune system. 10% of the liver is occupied by what are called Kupfer cells that are immune cells.

Those cells then speak to the brain through systemic circulation of messenger substances All these things were started to be developed out of that early 1990s recognition that this is a system that patterns the control that ultimately is seen in people with different ranges of symptoms of different duration, variety, and intensity.

And so we were setting the tone, I believe, in that early study for what later became the architecture for functional medicine as a systems biology approach towards healthcare.

There are three things that we collaboratively developed that have now stuck as clinical tools that I think are important to acknowledge as we move into this immune question. So let's just review quickly. I want to review quickly what really we have collaboratively developed as clinical therapeutic tools. Number one is gut restoration. We originally call it the four-hour program.

Now it's the five-hour program. We called it remove, replace, re-inoculate, repair. It was a way to actually intervene with patients that we could teach docs to understand pretty quickly that once they started doing this to the patients, the response they were getting was like, whoa. And then it caused them to see the paradigm shift.

So that was our first collaborative development of that algorithm that we called the 4-H program. Remove, replace, re-inoculate, repair. The next thing we worked on collaboratively.

Precisely. My first lecture, I recall, in fact, a doc sent me the notes from my first lecture on dysbiosis and leaky gut, 1985. So that was number one. Number two, which we collaborated on, which then also is tied to the immune system, has to do with the liver, and that's metabolic detoxification.

So what happens when stuff comes from the gut to the liver, which is the organ that has to process that, It has these processes that allow those molecules to be converted into non-toxic byproducts and be excreted that are called the detox pathways, phase one, phase two, phase three detox. We were the first people to really bring that up as a clinical therapeutic tool. Metabolic detoxification.

So that was another of our contributions to the field.

Yeah, I think that that's probably the thing that's helped it to go mainstream is when we develop the genetic ability to evaluate people's ability to detoxify drugs, both pharmacogenomics or pharmacogenetics, suddenly docs said, oh, that's right, I guess different people respond to drugs in different ways because they detoxify them in different ways.

It's the same metabolic pathways that are used to detoxify our foods and our foreign chemicals and xenobiotics. So suddenly now detox is in the main because of pharmacogenomics when docs have been criticizing that this is something specious.

Well, the third thing that we developed, which I think is equally important, and I take a pretty reasonable degree of pride in this, the first discussion that we ever had with physicians around bioenergetics and the energy powerhouse of the cell called the mitochondrion was in 1990. 1990, I introduced the concept of mitochondrial bioenergetics.

And that then, thanks to you and your colleagues, then people started to say, oh, maybe this is something related to fatigue. Maybe this is something related to muscle function. Maybe this is related to cognitive function. Gee, what cells are high in mitochondria? Oh, the cardiac cells, 70% of volume is mitochondria, the neurons in the brain. Gee whiz, all these cells that are really important

that are working hard for us 24-7 are really energy-rich mitochondria. What happens if mitochondria gets tired or is not functioning correctly? And so we developed a program called mitochondrial resuscitation. And we were the first people to start to actually provide a clinical intervention opportunity Now that's a standard affair.

And so this is the third thing that we all... Well, I wish it was a standard of care.

I think it's very important to recall that this was only as good as its ability to be taken up by a clinician that could then test this in patients. And you are the quintessential example of a person who saw the utility and the safety effects as it relates to its balance against the therapeutic effects and willingness to try this then with your patients in a very

discreet way that and codify that in such a way and to communicate it you're a marvelous obviously communicator both in writing and orally and i think that that

Showing 161–180 of 312 · page 9 of 16