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Dr. John Kruse

๐Ÿ‘ค Speaker
915 total appearances

Appearances Over Time

Podcast Appearances

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

If you forget to take your medicines in the morning, but you know you have a presentation at three that afternoon, you could take it and still be able to sleep that night. So it allows more flexibility, it allows more pinpointing of optimizing it for points the day you want to be using it.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

Some people philosophically say that in itself is wrong or bad, that you should be absolutely steady and constant because what we're trying to do is be consistent and reproducible. And others would say we're trying to treat individuals who have different demands on them and have different patterns during their day. So there are different philosophies about what's better or worse.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

Some people philosophically say that in itself is wrong or bad, that you should be absolutely steady and constant because what we're trying to do is be consistent and reproducible. And others would say we're trying to treat individuals who have different demands on them and have different patterns during their day. So there are different philosophies about what's better or worse.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

Some people philosophically say that in itself is wrong or bad, that you should be absolutely steady and constant because what we're trying to do is be consistent and reproducible. And others would say we're trying to treat individuals who have different demands on them and have different patterns during their day. So there are different philosophies about what's better or worse.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

One of the big downsides of the immediate release though is not only does it go in quickly, it tends to go off quickly. And most people, not all, but most experience some withdrawal as it's going off. And although when we're using this for ADHD, we focus on the cognitive executive function benefits, the focus, the attention, the concentration, and people can experience that.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

One of the big downsides of the immediate release though is not only does it go in quickly, it tends to go off quickly. And most people, not all, but most experience some withdrawal as it's going off. And although when we're using this for ADHD, we focus on the cognitive executive function benefits, the focus, the attention, the concentration, and people can experience that.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

One of the big downsides of the immediate release though is not only does it go in quickly, it tends to go off quickly. And most people, not all, but most experience some withdrawal as it's going off. And although when we're using this for ADHD, we focus on the cognitive executive function benefits, the focus, the attention, the concentration, and people can experience that.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

Many people who weren't even aware of it increasing their energy feel my energy is crashing as I go off of it. Or many people who weren't aware that it was actually elevating mood to any extent feel, oh my God, I'm crashing and I'm crying and cranky and miserable now. And with the extended release versions, most of them go in more gradually so it can be harder to detect.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

Many people who weren't even aware of it increasing their energy feel my energy is crashing as I go off of it. Or many people who weren't aware that it was actually elevating mood to any extent feel, oh my God, I'm crashing and I'm crying and cranky and miserable now. And with the extended release versions, most of them go in more gradually so it can be harder to detect.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

Many people who weren't even aware of it increasing their energy feel my energy is crashing as I go off of it. Or many people who weren't aware that it was actually elevating mood to any extent feel, oh my God, I'm crashing and I'm crying and cranky and miserable now. And with the extended release versions, most of them go in more gradually so it can be harder to detect.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

They last a longer period of the day. And most of them go out much more gradually at the end of the day. The one I like the most for a long-acting amphetamine product is Vyvanse. And Vyvanse was designed as a slow-release product. It was designed specifically to be unattractive to drug abusers. So Vyvanse chemically links the dexramphetamine molecule to lysine, one of the amino acids.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

They last a longer period of the day. And most of them go out much more gradually at the end of the day. The one I like the most for a long-acting amphetamine product is Vyvanse. And Vyvanse was designed as a slow-release product. It was designed specifically to be unattractive to drug abusers. So Vyvanse chemically links the dexramphetamine molecule to lysine, one of the amino acids.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

They last a longer period of the day. And most of them go out much more gradually at the end of the day. The one I like the most for a long-acting amphetamine product is Vyvanse. And Vyvanse was designed as a slow-release product. It was designed specifically to be unattractive to drug abusers. So Vyvanse chemically links the dexramphetamine molecule to lysine, one of the amino acids.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

It's a basic component of proteins and 20 essential amino acids. And if you snort it or inject it, you have an inactive prodrug. You have the list dexamphetamine. Your red blood cells actually have an enzyme that cleaves the lysine and leaves you with free active dextroamphetamine. And that's the slow release mechanism is how quickly your red blood cells can do it.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

It's a basic component of proteins and 20 essential amino acids. And if you snort it or inject it, you have an inactive prodrug. You have the list dexamphetamine. Your red blood cells actually have an enzyme that cleaves the lysine and leaves you with free active dextroamphetamine. And that's the slow release mechanism is how quickly your red blood cells can do it.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

It's a basic component of proteins and 20 essential amino acids. And if you snort it or inject it, you have an inactive prodrug. You have the list dexamphetamine. Your red blood cells actually have an enzyme that cleaves the lysine and leaves you with free active dextroamphetamine. And that's the slow release mechanism is how quickly your red blood cells can do it.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

And they have limited capacity to do that. So although they designed it... to be a anti-drug abuse drug, it actually turns out to be one of the sort of most consistently evenly entering the body. For some people it goes in so slowly that they say, I don't feel it. And also towards the end of the day one of the best in terms of not falling off abruptly.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

And they have limited capacity to do that. So although they designed it... to be a anti-drug abuse drug, it actually turns out to be one of the sort of most consistently evenly entering the body. For some people it goes in so slowly that they say, I don't feel it. And also towards the end of the day one of the best in terms of not falling off abruptly.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

And they have limited capacity to do that. So although they designed it... to be a anti-drug abuse drug, it actually turns out to be one of the sort of most consistently evenly entering the body. For some people it goes in so slowly that they say, I don't feel it. And also towards the end of the day one of the best in terms of not falling off abruptly.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

The potential downside is again that the capacity of the red blood cells is limited so at some point For most people, because that's a rate-limiting step, when you're adding more and more, you're actually extending the duration of time more than you're getting a bigger peak because your red blood cells just aren't cleaving it fast enough to make more dextroamphetamine available.