Dr. Keith Humphreys

That's good.

But there's lots of reasons that could come about.

It could be a common factor between those two things.

But the evidence has gotten stronger as the drug has gotten stronger and again we've got to realize people are using it much more intensely, so if this effect is there it's much more plausible that it would be from a much stronger drug used every day could generate higher rates of psychosis.

It's hard to test this because it's a rare thankfully condition, but I think there is...

probably something there, I'm sad to say, I wish there weren't, but there probably is something there.

I would not use cannabis if I had any first-degree relatives with any schizophrenia, anything in the psych, bipolar disorder, I would not personally recommend that for anybody.

I think that's probably quite risky.

I'm not sure of that, of non-smoked cannabis in the heart.

I mean, I haven't looked at that literature, so I don't know the answer to that.

I realize there's one point I should touch on that you also raised earlier about first drinking, which is...

Everything is different when the brain is plastic.

And our brains are most highly plastic when we're young.

And so a lot of these effects, the worst things are going to be because people start when they're young.

in teen or late single digit, that's where addictions overwhelmingly start.

And that is where if there is a psychotic risk, it's almost surely then during that period of brain development before people get their first psychotic break, which tends to be around 18, 19, 20, 21.

I worry about it less for anything, you know, initiating a substance when you're 50 is far less likely to end you up with an addiction or some other terrible thing than when you're young.

Yeah, absolutely true.

I mean, for example, I did Ezra Klein show, he's obviously a very successful guy and he mentioned that he sometimes uses cannabis edibles.

He has that look.