Dr. Kent Berridge
speaker
525 appearances
1 recordings
1 series
first heard Aug 2026
last heard 4 Aug
Dr. Kent Berridge’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 1 in all, peaking in Aug 2026 with 1.
Appearances
He was wondering if the dopamine blockade would suppress the liking ratings.
He probably still believed the dopamine pleasure hypothesis.
He did it a couple of ways.
One was to give a neuroleptic drug.
It might have been haloperidol or pemizide or might have been another antipsychotic dopamine.
It's a dopamine receptor D2 blocker.
It blocks D2 dopamine receptors.
The other way he did it was to ask them just before this experiment to drink a certain amino acid cocktail that competes with the synthesis of dopamine in the brain.
And it essentially stops the synthesis of dopamine for the next few hours.
Oh, wow.
Well, it's an antipsychotic.
It's the same drug that's prescribed for schizophrenia, and people don't really enjoy taking this drug.
Well…
For the COVID, it didn't block the pleasure, but it did reduce the wanting to take more.
So it was human confirmation that it was suppressing selectively wanting.
Now there's many, there's several kinds of dopamine receptors and these drugs just block the D2 kind.
There's a D1 kind and within them, there's several subcategories.
So it's blocking maybe half the dopamine receptors, but people who are prescribed it for schizophrenia who have to take it every day, they find that it kind of drains a lot of the zest out of life.
The incentive salience of life, when you walk out on a morning and the world is inviting, that's a dopamine kind of want.
That's a very adaptive, good kind of dopamine want.
Showing 181–200 of 525 · page 10 of 27
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